TY - JOUR
T1 - Hepatitis E Virus genotype 3 in Sewage and Genotype 1 in Acute Hepatitis Cases, Israel
AU - Ram, Daniela
AU - Manor, Yossi
AU - Gozlan, Yael
AU - Schwartz, Eli
AU - Ben-Ari, Ziv
AU - Mendelson, Ella
AU - Mor, Orna
N1 - Publisher Copyright:
© Copyright 2016 by The American Society of Tropical Medicine and Hygiene.
PY - 2016/7
Y1 - 2016/7
N2 - Hepatitis E virus (HEV) is an emerging infectious agent in developed countries. HEV genotypes 1 (G1) and 3 (G3) have been identified in environmental and clinical samples in Europe. In Israel, the overall prevalence of anti-HEV IgG antibodies was found to be 10.6%; however, reports of HEV infection are scarce. In this study, the presence of HEV in Israel was investigated using 169 sewage samples from 32 treatment facilities and 49 samples from acute hepatitis patients, all collected between 2013 and 2015. Fourteen sewage samples, from Haifa (11/18 samples), Tel Aviv (2/29 samples), and Beer Sheva (1/17 samples), regions with good sanitary conditions and middle-high socio economic populations, were HEV positive. Among the patient samples, 6.1% (3/49) were HEV positive, all returning travelers from India. Genotype analysis revealed G1 HEV in patients and G3 HEV sequences in sewage. Evidence that HEV could be establishing itself in our region may justify more active surveillance to monitor its spread.
AB - Hepatitis E virus (HEV) is an emerging infectious agent in developed countries. HEV genotypes 1 (G1) and 3 (G3) have been identified in environmental and clinical samples in Europe. In Israel, the overall prevalence of anti-HEV IgG antibodies was found to be 10.6%; however, reports of HEV infection are scarce. In this study, the presence of HEV in Israel was investigated using 169 sewage samples from 32 treatment facilities and 49 samples from acute hepatitis patients, all collected between 2013 and 2015. Fourteen sewage samples, from Haifa (11/18 samples), Tel Aviv (2/29 samples), and Beer Sheva (1/17 samples), regions with good sanitary conditions and middle-high socio economic populations, were HEV positive. Among the patient samples, 6.1% (3/49) were HEV positive, all returning travelers from India. Genotype analysis revealed G1 HEV in patients and G3 HEV sequences in sewage. Evidence that HEV could be establishing itself in our region may justify more active surveillance to monitor its spread.
UR - http://www.scopus.com/inward/record.url?scp=84977602300&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.15-0925
DO - 10.4269/ajtmh.15-0925
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C2 - 27246446
AN - SCOPUS:84977602300
SN - 0002-9637
VL - 95
SP - 216
EP - 220
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -
