Hepatitis B Vaccination and Autoimmunity

Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld, Dimitrios P. Bogdanos

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Hepatitis B vaccine (HBVacc) protects against hepatitis B, a major infectious disease that can cause cirrhosis and hepatocellular cancer. The vaccines developed to date are generally effective and safe. However, HBvacc has been implicated in the pathogenesis of autoimmune phenomena. Crossreactivity with HBsAg epitopes, yeast antigens, and toxic or other immune-mediated phenomena caused by adjuvants has been considered responsible for the induction of HBvacc-mediated phenomena. Particular attention has been given to the alleged association between HBvacc and multiple sclerosis (MS) and other immune-mediated neurological associations. This chapter discusses in great detail the role played by HBVacc in the development of autoimmune diseases, including MS and other neuromuscular disorders, autoimmune skin and vascular disease, and other autoimmune diseases.

Original languageEnglish
Title of host publicationVaccines and Autoimmunity
Number of pages16
ISBN (Electronic)9781118663721
ISBN (Print)9781118663431
StatePublished - 1 Jan 2014


  • Autoimmunity
  • Hepatitis
  • Infection
  • Safety
  • Vaccination


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