Hepatitis B Vaccination and Autoimmunity

Daniel S. Smyk; Lazaros I. Sakkas; Yehuda Shoenfeld; Dimitrios P. Bogdanos

doi:10.1002/9781118663721.ch16

Hepatitis B Vaccination and Autoimmunity

Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld, Dimitrios P. Bogdanos

Clinical Departments

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Hepatitis B vaccine (HBVacc) protects against hepatitis B, a major infectious disease that can cause cirrhosis and hepatocellular cancer. The vaccines developed to date are generally effective and safe. However, HBvacc has been implicated in the pathogenesis of autoimmune phenomena. Crossreactivity with HBsAg epitopes, yeast antigens, and toxic or other immune-mediated phenomena caused by adjuvants has been considered responsible for the induction of HBvacc-mediated phenomena. Particular attention has been given to the alleged association between HBvacc and multiple sclerosis (MS) and other immune-mediated neurological associations. This chapter discusses in great detail the role played by HBVacc in the development of autoimmune diseases, including MS and other neuromuscular disorders, autoimmune skin and vascular disease, and other autoimmune diseases.

Original language	English
Title of host publication	Vaccines and Autoimmunity
Publisher	Wiley-Blackwell
Pages	147-162
Number of pages	16
ISBN (Electronic)	9781118663721
ISBN (Print)	9781118663431
DOIs	https://doi.org/10.1002/9781118663721.ch16
State	Published - 1 Jan 2014

Keywords

Autoimmunity
Hepatitis
Infection
Safety
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/9781118663721.ch16

Cite this

@inbook{d72069875d004c6caf3aeb3a16fc6f90,

title = "Hepatitis B Vaccination and Autoimmunity",

abstract = "Hepatitis B vaccine (HBVacc) protects against hepatitis B, a major infectious disease that can cause cirrhosis and hepatocellular cancer. The vaccines developed to date are generally effective and safe. However, HBvacc has been implicated in the pathogenesis of autoimmune phenomena. Crossreactivity with HBsAg epitopes, yeast antigens, and toxic or other immune-mediated phenomena caused by adjuvants has been considered responsible for the induction of HBvacc-mediated phenomena. Particular attention has been given to the alleged association between HBvacc and multiple sclerosis (MS) and other immune-mediated neurological associations. This chapter discusses in great detail the role played by HBVacc in the development of autoimmune diseases, including MS and other neuromuscular disorders, autoimmune skin and vascular disease, and other autoimmune diseases.",

keywords = "Autoimmunity, Hepatitis, Infection, Safety, Vaccination",

author = "Smyk, {Daniel S.} and Sakkas, {Lazaros I.} and Yehuda Shoenfeld and Bogdanos, {Dimitrios P.}",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley-Blackwell.",

year = "2014",

month = jan,

day = "1",

doi = "10.1002/9781118663721.ch16",

language = "אנגלית",

isbn = "9781118663431",

pages = "147--162",

booktitle = "Vaccines and Autoimmunity",

publisher = "Wiley-Blackwell",

}

TY - CHAP

T1 - Hepatitis B Vaccination and Autoimmunity

AU - Smyk, Daniel S.

AU - Sakkas, Lazaros I.

AU - Shoenfeld, Yehuda

AU - Bogdanos, Dimitrios P.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Hepatitis B vaccine (HBVacc) protects against hepatitis B, a major infectious disease that can cause cirrhosis and hepatocellular cancer. The vaccines developed to date are generally effective and safe. However, HBvacc has been implicated in the pathogenesis of autoimmune phenomena. Crossreactivity with HBsAg epitopes, yeast antigens, and toxic or other immune-mediated phenomena caused by adjuvants has been considered responsible for the induction of HBvacc-mediated phenomena. Particular attention has been given to the alleged association between HBvacc and multiple sclerosis (MS) and other immune-mediated neurological associations. This chapter discusses in great detail the role played by HBVacc in the development of autoimmune diseases, including MS and other neuromuscular disorders, autoimmune skin and vascular disease, and other autoimmune diseases.

AB - Hepatitis B vaccine (HBVacc) protects against hepatitis B, a major infectious disease that can cause cirrhosis and hepatocellular cancer. The vaccines developed to date are generally effective and safe. However, HBvacc has been implicated in the pathogenesis of autoimmune phenomena. Crossreactivity with HBsAg epitopes, yeast antigens, and toxic or other immune-mediated phenomena caused by adjuvants has been considered responsible for the induction of HBvacc-mediated phenomena. Particular attention has been given to the alleged association between HBvacc and multiple sclerosis (MS) and other immune-mediated neurological associations. This chapter discusses in great detail the role played by HBVacc in the development of autoimmune diseases, including MS and other neuromuscular disorders, autoimmune skin and vascular disease, and other autoimmune diseases.

KW - Autoimmunity

KW - Hepatitis

KW - Infection

KW - Safety

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=85026310428&partnerID=8YFLogxK

U2 - 10.1002/9781118663721.ch16

DO - 10.1002/9781118663721.ch16

M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.chapter???

AN - SCOPUS:85026310428

SN - 9781118663431

SP - 147

EP - 162

BT - Vaccines and Autoimmunity

PB - Wiley-Blackwell

ER -

Hepatitis B Vaccination and Autoimmunity

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this