Hepatic iron overload: Quantitative MR imaging

John M. Gomori, Gadi Horev, Hannah Tamary, Judith Zandback, Liora Kornreich, Rina Zaizov, Enrique Freud, Oliver Krief, Joseph Ben-Meir, Haim Rotem, Mario Kuspet, Phillip Rosen, Eliezer A. Rachmilewitz, Elia Loewenthal, Raphael Gorodetsky

Research output: Contribution to journalArticlepeer-review

Abstract

Iron deposits demonstrate characteristically shortened T2 relaxation times. Several previously published studies reported poor correlation between the in vivo hepatic 1/T2 measurements made by means of midfield magnetic resonance (MR) units and the hepatic iron content of iron-overloaded patients. In this study, the authors assessed the use of in vivo 1/T2 measurements obtained by means of MR imaging at 0.5 T using short echo times (13.4 and 30 msec) and single-echo sequences as well as computed tomographic (CT) attenuation as a measure of liver iron concentration in 10 severely iron-overloaded patients with β-thalassemia major. The iron concentrations in surgical wedge biopsy samples of the liver, which varied between 3 and 9 mg/g of wet weight (normal, ≤0.5 mg/g), correlated well (r = .93, P ≤ .0001) with the preoperative in vivo hepatic 1/ T2 measurements. The CT attenuation did not correlate with liver iron concentration. Quantitative MR imaging is a readily available noninvasive method for the assessment of hepatic iron concentration in iron-overloaded patients, reducing the need for needle biopsies of the liver.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalRadiology
Volume179
Issue number2
DOIs
StatePublished - May 1991
Externally publishedYes

Keywords

  • Anemia, 761.652
  • Liver, diseases, 761.594, 761.652
  • Liver, iron content, 761.652
  • Liver, mr studies, 761.1214
  • Magnetic resonance (mr), comparative studies

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