Heparin receptors on mouse macrophages

I. Bleiberg*, I. MacGregor, M. Aronson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study deals with the nature of the attachment between the macrophage cell membrane and heparin molecules. Treatments intended to remove or internalise macrophage receptors (trypsinisation and stimulation of phagocytosis respectively) were shown to considerably modulate the attachment of heparin. An excess of heparin fractions ranging in mean molecular weight from 8100 to 25700 all inhibited attachment of 35S heparin as did a mixed isomer chondroitin sulphate preparation. Our study provides evidence for the presence of receptors for sulphated glycosaminoglycans on the mouse macrophage cell membrane.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalThrombosis Research
Volume29
Issue number1
DOIs
StatePublished - 1 Jan 1983

Keywords

  • Heparin fractions
  • heparin receptors
  • macrophages

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