TY - JOUR
T1 - Heparin-induced thrombocytopenia and extracorporeal membrane oxygenation
T2 - A case report and review of the literature
AU - Pollak, Uri
AU - Yacobobich, Joanne
AU - Tamary, Hannah
AU - Dagan, Ovdi
AU - Manor-Shulman, Orit
N1 - Funding Information:
This work was supported by the Office of Naval Research, the University of Maryland through Minta Martin Endowment Funds in the Department of Aerospace Engineering, and the Glenn L. Martin Institute Chaired Professorship at the A. James Clark School of Engineering. The computations were carried out on University of Maryland supercomputing resources (http://www.it.umd.edu/hpcc). The authors thank David Kessler and Fokion Egolfopoulos for their assistance in developing the chemical model used in these simulations, as well as Vadim Gamezo for sharing his insights on DDT in channels with obstacles. The authors particularly acknowledge the help of Alp Ozgen in determining the optimal chemical-diffusive model.
PY - 2011/3
Y1 - 2011/3
N2 - Heparin-induced thrombocytopenia (HIT) is an immunemediated coagulation side effect of heparin therapy characterized by thrombocytopenia and by a paradoxical prothrombotic state following heparin exposure when thrombotic or thromboembolic events accurse, the condition is classified as Heparin-induced thrombocytopenia with thrombosis (HITT). We report a case of HITT with evidence of small-vessel arterial thrombosis in a 5-day-old newborn receiving extracorporeal membrane oxygenation (ECMO) for congenital diaphragmatic hernia, and our attempt of bivalirudin alternative treatment. We also review previous reports regarding HIT and ECMO with the alternative management in this unique population.
AB - Heparin-induced thrombocytopenia (HIT) is an immunemediated coagulation side effect of heparin therapy characterized by thrombocytopenia and by a paradoxical prothrombotic state following heparin exposure when thrombotic or thromboembolic events accurse, the condition is classified as Heparin-induced thrombocytopenia with thrombosis (HITT). We report a case of HITT with evidence of small-vessel arterial thrombosis in a 5-day-old newborn receiving extracorporeal membrane oxygenation (ECMO) for congenital diaphragmatic hernia, and our attempt of bivalirudin alternative treatment. We also review previous reports regarding HIT and ECMO with the alternative management in this unique population.
KW - Bivalirudin
KW - Direct thrombin inhibitor
KW - Extracorporeal membrane oxygenation
KW - Heparin-induced thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=79952968427&partnerID=8YFLogxK
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C2 - 21449228
AN - SCOPUS:79952968427
VL - 43
SP - 5
EP - 12
JO - Journal of Extra-Corporeal Technology
JF - Journal of Extra-Corporeal Technology
SN - 0022-1058
IS - 1
ER -