Heparanase expression in Langerhans cell histiocytosis

Rina Dvir*, Israel Vlodavsky, Neta Ilan, Menachem Bitan, Josephine Issacov, Ronit Elhasid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Heparanase is an endo-beta D-glucuronidase capable of cleaving heparan sulfate side chains, yielding heparan sulfate fragments. Heparanase activity has been correlated with the metastatic potential of tumor-derived cells, angiogenesis, autoimmunity and inflammation. We performed a study of heparanase expression in specimens obtained from patients with Langerhans cell histiocytosis (LCH). Paraffin embedded slides from 25 patients were studied by immunohistochemistry for heparanase. Most patients had positive staining for heparanase (21/25). There was no positive association with severity of disease and other clinical characteristics. Further studies are required to clarify the role of heparanase in the pathogenesis of LCH.

Original languageEnglish
Pages (from-to)1883-1885
Number of pages3
JournalPediatric Blood and Cancer
Issue number10
StatePublished - Oct 2014


  • Heparanase
  • Histiocytosis
  • Langerhans


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