Hemophagocytic syndrome

I. Morag*, M. Goldman, T. Bistrizer, C. Kaplinsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Hemophagocytic syndrome is a rare, fulminant disease characterized by generalized histiocytic proliferation associated with phagocytosis of erythrocytes, platelets, and to a lesser extent, of white blood cells. We report a 2-year-old boy admitted with high fever and irritability, with a rash, marked hepatomegaly and generalized lymphadenopathy. Liver function tests were abnormal and there was thrombocytopenia and hyperlipidemia. Bone marrow aspiration revealed hemophagocytosis. Despite intensive treatment with steroids, intravenous immunoglobulin and cytotoxic drugs, he died within 10 weeks.

Original languageEnglish
Pages (from-to)609-611, 679
Issue number12
StatePublished - 15 Dec 1999
Externally publishedYes


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