TY - JOUR
T1 - Hemodynamic forces as a stimulus for arteriogenesis
AU - Resnick, Nitzan
AU - Einav, Shmeul
AU - Chen-Konak, Limor
AU - Zilberman, Michal
AU - Yahav, Hava
AU - Shay-Salit, Ayelet
N1 - Funding Information:
Received 17 May 2003; accepted 6 August 2003. This study was supported by the Israeli Academy of Sciences (436-02), The Israeli Ministry of Health (4988), and the Israeli Science Ministry 01-299-01-01 (NR). LC-K is The Ministry of Science Eshkol Fellow. Address correspondence to Nitzan Resnick, Ph.D., Rappaport Institute, POB 9697, Haifa 31096, Israel. E-mail: [email protected]
PY - 2003
Y1 - 2003
N2 - Ischemic heart diseases put a heavy economical burden on Western society. They remain one of the major causes of morbidity, and preventive or postoperative treatments are lengthy and expensive. In some patients of ischemic heart diseases, there is not a direct correlation between the degree of occlusion of major arteries and the development of medical symptoms or damage to the heart function. Interestingly, these patients develop well-formed collateral vessels that compensate for the decrease in blood supply to the heart wall. Clearly, the ability to understand why and how these patients develop collateral vessels may serve as a base for a new strategy to treat ischemic heart diseases by promoting collateral formation. The current article summarizes recent advances in the understanding of how collateral vessels develop and offers the authors' point of view on the central role of biomechanical forces in this process and the molecular mechanisms that underline it.
AB - Ischemic heart diseases put a heavy economical burden on Western society. They remain one of the major causes of morbidity, and preventive or postoperative treatments are lengthy and expensive. In some patients of ischemic heart diseases, there is not a direct correlation between the degree of occlusion of major arteries and the development of medical symptoms or damage to the heart function. Interestingly, these patients develop well-formed collateral vessels that compensate for the decrease in blood supply to the heart wall. Clearly, the ability to understand why and how these patients develop collateral vessels may serve as a base for a new strategy to treat ischemic heart diseases by promoting collateral formation. The current article summarizes recent advances in the understanding of how collateral vessels develop and offers the authors' point of view on the central role of biomechanical forces in this process and the molecular mechanisms that underline it.
KW - Hemodynamic forces
KW - Shear-stress receptors
KW - Signaling
KW - Vascular endothelium
KW - Vascular remodeling
UR - http://www.scopus.com/inward/record.url?scp=0345737220&partnerID=8YFLogxK
U2 - 10.1080/713715231
DO - 10.1080/713715231
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AN - SCOPUS:0345737220
SN - 1062-3329
VL - 10
SP - 197
EP - 206
JO - Endothelium: Journal of Endothelial Cell Research
JF - Endothelium: Journal of Endothelial Cell Research
IS - 4-5
ER -