TY - JOUR
T1 - Hemispheric disconnection and rotational behaviour
AU - Mintz, Matti
AU - Douglas, Rodney
AU - Kellaway, Lauriston
AU - Van Wageningen, Gerard
N1 - Funding Information:
This project was funded by an SA MRC grant to R D M M acknowledges a travel grant from the Department of Physiology, Umverslty of Cape Town Medical School We are grateful to Prof J Taljaard and Mms A de Vllhers of the MRC Unit for the Neurochermstry of Mental Diseases for neurochermcal estlmataons
PY - 1985/10
Y1 - 1985/10
N2 - Several studies have demonstrated the existence of crossed pathways interconnecting the bilateral extrapyramidal system. The present study has evaluated the role of the thalamus in the interhemispheric control of nigrostriatal function by observing the effect of midsagittal thalamic transection on amphetamine-induced rotation in rats. The effect of thalamic transection on net rotational asymmetry did not differ from the effects of sham operations. Also, the transection did not affect the rotational asymmetry induced by subsequent lesioning of the dominant hemisphere substantia nigra. The failure to affect the rotation asymmetry by the transection suggests either that the inter-hemispheric pathway does not control extrapyramidal asymmetry or that the crossing takes place outside the thalamus. In an additional group of rats, thalamic transection did not interrupt retrograde labeling of somata in the substantia nigra and ventral tegmental area by horseradish peroxidase injected in the contralateral caudate. Thus, the crossed nigrostriatal projection does not decussate via the thalamus. It is suggested that this pathway decussates in the ventral mesencephalon.
AB - Several studies have demonstrated the existence of crossed pathways interconnecting the bilateral extrapyramidal system. The present study has evaluated the role of the thalamus in the interhemispheric control of nigrostriatal function by observing the effect of midsagittal thalamic transection on amphetamine-induced rotation in rats. The effect of thalamic transection on net rotational asymmetry did not differ from the effects of sham operations. Also, the transection did not affect the rotational asymmetry induced by subsequent lesioning of the dominant hemisphere substantia nigra. The failure to affect the rotation asymmetry by the transection suggests either that the inter-hemispheric pathway does not control extrapyramidal asymmetry or that the crossing takes place outside the thalamus. In an additional group of rats, thalamic transection did not interrupt retrograde labeling of somata in the substantia nigra and ventral tegmental area by horseradish peroxidase injected in the contralateral caudate. Thus, the crossed nigrostriatal projection does not decussate via the thalamus. It is suggested that this pathway decussates in the ventral mesencephalon.
KW - asymmetry
KW - crossed nigrostriatal pathway
KW - horseradish peroxidase
KW - midsagittal thalamic transection
KW - rat
KW - rotation
UR - http://www.scopus.com/inward/record.url?scp=0022345404&partnerID=8YFLogxK
U2 - 10.1016/0166-4328(85)90050-6
DO - 10.1016/0166-4328(85)90050-6
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AN - SCOPUS:0022345404
VL - 17
SP - 257
EP - 263
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 3
ER -