Hemispheric disconnection and rotational behaviour

Matti Mintz, Rodney Douglas, Lauriston Kellaway, Gerard Van Wageningen

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies have demonstrated the existence of crossed pathways interconnecting the bilateral extrapyramidal system. The present study has evaluated the role of the thalamus in the interhemispheric control of nigrostriatal function by observing the effect of midsagittal thalamic transection on amphetamine-induced rotation in rats. The effect of thalamic transection on net rotational asymmetry did not differ from the effects of sham operations. Also, the transection did not affect the rotational asymmetry induced by subsequent lesioning of the dominant hemisphere substantia nigra. The failure to affect the rotation asymmetry by the transection suggests either that the inter-hemispheric pathway does not control extrapyramidal asymmetry or that the crossing takes place outside the thalamus. In an additional group of rats, thalamic transection did not interrupt retrograde labeling of somata in the substantia nigra and ventral tegmental area by horseradish peroxidase injected in the contralateral caudate. Thus, the crossed nigrostriatal projection does not decussate via the thalamus. It is suggested that this pathway decussates in the ventral mesencephalon.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalBehavioural Brain Research
Volume17
Issue number3
DOIs
StatePublished - Oct 1985

Keywords

  • asymmetry
  • crossed nigrostriatal pathway
  • horseradish peroxidase
  • midsagittal thalamic transection
  • rat
  • rotation

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