Hemispheric brain damage in unilateral status epilepticus

Dov Soffer*, Eldad Melamed, Yaakov Assaf, Shamay Cotev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 20‐year‐old woman with psychomotor seizures developed prolonged unilateral status epilepticus followed by coma, right hemiparesis, fever, liver failure, and eventually death. Neuropathological findings included severe neuronal ischemic cell change and massive brain edema, essentially restricted to the left cerebral hemisphere. Massive destruction of the hemisphere involved in epileptic activity with sparing of the contralateral hemisphere provides supportive evidence that in humans prolonged seizure activity can cause permanent brain damage.

Original languageEnglish
Pages (from-to)737-740
Number of pages4
JournalAnnals of Neurology
Issue number6
StatePublished - Dec 1986
Externally publishedYes


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