Hemiasterlin and geodiamolide TA; two new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick)

R. Talpir, Y. Benayahu, Y. Kashman, L. Pannell, M. Schleyer

Research output: Contribution to journalArticlepeer-review

Abstract

Three cytotoxic peptides, Jaspamide (1) and the two new peptides hemiasterlin (2) and geodiamolide TA (3), have been isolated from the sponge Hemiasterella minor. The structures of the three were determined by interpretating the NMR and mass spectra. Hemiasterlin (2) is a novel linear tripeptide embodying two unique, new natural aminoacids and geodiamolide TA (3) is a higher homologe of geodiamolides A-F.

Original languageEnglish
Pages (from-to)4453-4456
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number25
DOIs
StatePublished - 20 Jun 1994

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