TY - JOUR
T1 - Hematopoetic stem cell transplantation in neutrophil disorders
T2 - Severe congenital neutropenia, leukocyte adhesion deficiency and chronic granulomatous disease
AU - Elhasid, Ronit
AU - Rowe, Jacob M.
PY - 2010/2
Y1 - 2010/2
N2 - Until further progress will occur in the field of gene therapy, the only curative treatment available in severe congenital neutropenia, leukocyte adhesion deficiency, and chronic granulomatous disease is allogeneic hematopoietic stem cell transplantation (HSCT). This review summarizes the current data regarding indications for transplantation in each disease, treatment results using related and unrelated donors, as well as toxicity of HSCT in the above diseases.
AB - Until further progress will occur in the field of gene therapy, the only curative treatment available in severe congenital neutropenia, leukocyte adhesion deficiency, and chronic granulomatous disease is allogeneic hematopoietic stem cell transplantation (HSCT). This review summarizes the current data regarding indications for transplantation in each disease, treatment results using related and unrelated donors, as well as toxicity of HSCT in the above diseases.
KW - Chronic granulomatous disease
KW - Hematopoietic stem cell transplantation (HSCT)
KW - Leukocyte adhesion deficiency
KW - Severe congenital neutropenia
UR - http://www.scopus.com/inward/record.url?scp=75949086263&partnerID=8YFLogxK
U2 - 10.1007/s12016-009-8129-y
DO - 10.1007/s12016-009-8129-y
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C2 - 19452286
AN - SCOPUS:75949086263
SN - 1080-0549
VL - 38
SP - 61
EP - 67
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
IS - 1
ER -