Helminthes and Autoimmunity, a Love Story

Sharon Slomovich*, Hanan Guzner-Gur, Miri Blank, Yehuda Shoenfeld

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The hygiene theory represents environmental aspects that modulate the risk for developing autoimmune diseases. There is a reverse correlation between the presence of helminthes and the flare of autoimmune diseases, explaining the rise in the incidence of certain autoimmune diseases in developed countries. The protective properties of certain helminths is attributed to their secretory compounds that immunomodulate the host immune system to survive. The chapter provides a glimpse on several helminth-secrteted products that has a role in the immunomodulation of the host immune network.

Original languageEnglish
Title of host publicationMosaic of Autoimmunity
Subtitle of host publicationThe Novel Factors of Autoimmune Diseases
Number of pages4
ISBN (Electronic)9780128143087
ISBN (Print)9780128143070
StatePublished - 13 Feb 2019


  • Autoimmunity
  • Helminth
  • Murine models
  • Secretory molecules
  • TPC


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