Helicobacter pylori -negative Chronic Gastritis in Children: A Systematic Review

Amit Assa, Osvaldo Borrelli, Ilse Broekaert, Marco Deganello Saccomani, Jernej Dolinsek, Javier Martin-De-Carpi, Emmanuel Mas, Erasmo Miele, Sara Sila, Mike Thomson, Christos Tzivinikos, Marc A. Benninga

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objectives:To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes.Methods:Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included.Results:A total of 54 studies were included consisted of eosinophilic gastritis (n=9), autoimmune gastritis (n=11), collagenous gastritis (n=16), focally enhanced gastritis (n=6), lymphocytic gastritis (n=5) and other causes including idiopathic gastritis and chronic renal failure related (n=7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%-45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses.Conclusions:Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.

Original languageEnglish
Pages (from-to)956-967
Number of pages12
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number5
StatePublished - 1 May 2022
Externally publishedYes


FundersFunder number
Janssen Pharmaceutica


    • autoimmune
    • collagenous
    • eosinophilic
    • gastric
    • lymphocytic
    • paediatric
    • ulcers


    Dive into the research topics of 'Helicobacter pylori -negative Chronic Gastritis in Children: A Systematic Review'. Together they form a unique fingerprint.

    Cite this