TY - JOUR
T1 - Helicobacter pylori -negative Chronic Gastritis in Children
T2 - A Systematic Review
AU - Assa, Amit
AU - Borrelli, Osvaldo
AU - Broekaert, Ilse
AU - Saccomani, Marco Deganello
AU - Dolinsek, Jernej
AU - Martin-De-Carpi, Javier
AU - Mas, Emmanuel
AU - Miele, Erasmo
AU - Sila, Sara
AU - Thomson, Mike
AU - Tzivinikos, Christos
AU - Benninga, Marc A.
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Objectives:To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes.Methods:Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included.Results:A total of 54 studies were included consisted of eosinophilic gastritis (n=9), autoimmune gastritis (n=11), collagenous gastritis (n=16), focally enhanced gastritis (n=6), lymphocytic gastritis (n=5) and other causes including idiopathic gastritis and chronic renal failure related (n=7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%-45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses.Conclusions:Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.
AB - Objectives:To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes.Methods:Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included.Results:A total of 54 studies were included consisted of eosinophilic gastritis (n=9), autoimmune gastritis (n=11), collagenous gastritis (n=16), focally enhanced gastritis (n=6), lymphocytic gastritis (n=5) and other causes including idiopathic gastritis and chronic renal failure related (n=7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%-45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses.Conclusions:Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.
KW - autoimmune
KW - collagenous
KW - eosinophilic
KW - gastric
KW - lymphocytic
KW - paediatric
KW - ulcers
UR - http://www.scopus.com/inward/record.url?scp=85130642330&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000003414
DO - 10.1097/MPG.0000000000003414
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C2 - 35175996
AN - SCOPUS:85130642330
SN - 0277-2116
VL - 74
SP - 956
EP - 967
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 5
ER -