TY - JOUR
T1 - Helicobacter pylori Diagnostic Tests Used in Europe
T2 - Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
AU - on behalf of Hp-EuReg Investigators
AU - García-Morales, Natalia
AU - Pérez-Aísa, Ángeles
AU - Fiorini, Giulia
AU - Tepes, Bojan
AU - Castro-Fernández, Manuel
AU - Lucendo, Alfredo
AU - Voynovan, Irina
AU - Bujanda, Luis
AU - Garre, Ana
AU - Rodrigo, Luis
AU - Martínez Domínguez, Samuel Jesús
AU - Denkovski, Maja
AU - Huguet Malavés, Jose M.
AU - Jonaitis, Laimas
AU - Bumane, Renate
AU - Zaytsev, Oleg
AU - Mata Romero, Pilar
AU - Barrio, Jesús
AU - Fernández-Salazar, Luis
AU - Sarsenbaeva, Aiman Silkanovna
AU - Ortiz Polo, Inmaculada
AU - Alekseenko, Sergey
AU - Saracino, Ilaria Maria
AU - Vaira, Dino
AU - Keco-Huerga, Alma
AU - Bordin, Dmitry
AU - Gasbarrini, Antonio
AU - Lerang, Frode
AU - Rokkas, Theodore
AU - Kupčinskas, Juozas
AU - Leja, Marcis
AU - Babayeva, Gulustan
AU - Marcos Pinto, Ricardo
AU - Tonkić, Ante
AU - Smith, Sinead
AU - Phull, Perminder
AU - Buzas, Gyorgy M.
AU - Simsek, Halis
AU - Boltin, Doron
AU - Gridnyev, Oleksiy
AU - Venerito, Marino
AU - Milivojevic, Vladimir
AU - Torà, Núria
AU - Cano-Català, Anna
AU - Moreira, Leticia
AU - Nyssen, Olga P.
AU - Mégraud, Francis
AU - O’Morain, Colm
AU - Gisbert, Javier P.
AU - Puig, Ignasi
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/7
Y1 - 2023/7
N2 - Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored.
AB - Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored.
KW - Helicobacter pylori
KW - diagnostic tests
KW - gastrointestinal endoscopy
KW - histology
KW - urea breath test
UR - http://www.scopus.com/inward/record.url?scp=85165136606&partnerID=8YFLogxK
U2 - 10.3390/jcm12134363
DO - 10.3390/jcm12134363
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C2 - 37445399
AN - SCOPUS:85165136606
SN - 2077-0383
VL - 12
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 13
M1 - 4363
ER -