Yoram Epstein*, Ran Yanovich

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

300 Scopus citations


Heatstroke is the most hazardous condition in a spectrum of illnesses progressing from heat exhaustion to heatstroke, in which a shared finding is hyperthermia (i.e., the rise in core body temperature when heat accumulation overrides heat dissipation during exercise or exposure to environmental heat stress).1 Clinically, heatstroke is characterized by central nervous system (CNS) dysfunction, multiorgan failure, and extreme hyperthermia (usually >40.5°C).2,3 This review summarizes current knowledge about heatstroke, which is often misinterpreted or overlooked, focusing on its relevance for medical practitioners.

Original languageEnglish
Pages (from-to)2449-2459
Number of pages11
JournalNew England Journal of Medicine
Issue number25
StatePublished - 20 Jun 2019


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