TY - GEN
T1 - Heat-shock protein 65 autoantibodies are differently associated with early atherosclerosis in rheumatoid arthritis and in healthy subjects
AU - Sherer, Yaniv
AU - Gerli, Roberto
AU - Bocci, Elena Bartoloni
AU - Gilburd, Boris
AU - Vaudo, Gaetano
AU - Bistoni, Onelia
AU - Shoenfeld, Yehuda
PY - 2007/6
Y1 - 2007/6
N2 - The aim of this study was to examine whether heat-shock protein (HSP)-65 autoantibodies are associated with early atherosclerosis in rheumatoid arthritis (RA). Intima-media thickness (IMT) was measured in the carotid arteries of 100 RA patients and 69 control subjects. The IMT was evaluated on both carotid arteries in the common carotid, bifurcation, and internal arteries. Every patient underwent anti-HSP-65 antibody evaluation. Anti-HSP-65 antibodies were not more prevalent among patients compared with controls. Among controls, patients having "positive" anti-HSP-65 tended to have increased carotid artery IMT compared with "negative" patients, whereas among RA patients the opposite association was noted, and positive patients had significantly decreased carotid bifurcation IMT than negative patients without elevated levels of anti-HSP-65. As opposed to the association with cardiovascular diseases and atherosclerosis of anti-HSPs in the general population, among RA patients anti-HSP-65 cannot be regarded as associated with early atherosclerosis.
AB - The aim of this study was to examine whether heat-shock protein (HSP)-65 autoantibodies are associated with early atherosclerosis in rheumatoid arthritis (RA). Intima-media thickness (IMT) was measured in the carotid arteries of 100 RA patients and 69 control subjects. The IMT was evaluated on both carotid arteries in the common carotid, bifurcation, and internal arteries. Every patient underwent anti-HSP-65 antibody evaluation. Anti-HSP-65 antibodies were not more prevalent among patients compared with controls. Among controls, patients having "positive" anti-HSP-65 tended to have increased carotid artery IMT compared with "negative" patients, whereas among RA patients the opposite association was noted, and positive patients had significantly decreased carotid bifurcation IMT than negative patients without elevated levels of anti-HSP-65. As opposed to the association with cardiovascular diseases and atherosclerosis of anti-HSPs in the general population, among RA patients anti-HSP-65 cannot be regarded as associated with early atherosclerosis.
KW - Autoantibody
KW - Heat-shock protein-65
KW - Intima-media thickness
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=34948856922&partnerID=8YFLogxK
U2 - 10.1196/annals.1422.042
DO - 10.1196/annals.1422.042
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C2 - 17894004
AN - SCOPUS:34948856922
SN - 157331708X
SN - 9781573317085
T3 - Annals of the New York Academy of Sciences
SP - 408
EP - 413
BT - Autoimmunity, Part D
PB - Blackwell Publishing Inc.
ER -
