Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease

Naomi P. Visanji; Grace S. Bhudhikanok; Tiago A. Mestre; Taneera Ghate; Kaviraj Udupa; Amaal AlDakheel; Barbara S. Connolly; Carmen Gasca-Salas; Drew S. Kern; Jennifer Jain; Elizabeth J. Slow; Achinoam Faust-Socher; Sam Kim; Ruksana Azhu Valappil; Farah Kausar; Ekaterina Rogaeva; J. William Langston; Caroline M. Tanner; Birgitt Schüle; Anthony E. Lang; Samuel M. Goldman; Connie Marras

doi:10.1002/mds.26896

Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease

Naomi P. Visanji^*, Grace S. Bhudhikanok, Tiago A. Mestre, Taneera Ghate, Kaviraj Udupa, Amaal AlDakheel, Barbara S. Connolly, Carmen Gasca-Salas, Drew S. Kern, Jennifer Jain, Elizabeth J. Slow, Achinoam Faust-Socher, Sam Kim, Ruksana Azhu Valappil, Farah Kausar, Ekaterina Rogaeva, J. William Langston, Caroline M. Tanner, Birgitt Schüle, Anthony E. LangSamuel M. Goldman, Connie Marras

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. Objectives: This study investigated heart rate variability in LRRK2-associated PD. Methods: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration. Results: Low-frequency power and the ratio of low–high frequency power were reduced in idiopathic PD versus controls (P <.008, P <.029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD. Conclusions: Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD.

Original language	English
Pages (from-to)	610-614
Number of pages	5
Journal	Movement Disorders
Volume	32
Issue number	4
DOIs	https://doi.org/10.1002/mds.26896
State	Published - Apr 2017
Externally published	Yes

Keywords

LRRK2
Parkinson's disease
autonomic dysfunction
heart rate variability

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10.1002/mds.26896

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Visanji, N. P., Bhudhikanok, G. S., Mestre, T. A., Ghate, T., Udupa, K., AlDakheel, A., Connolly, B. S., Gasca-Salas, C., Kern, D. S., Jain, J., Slow, E. J., Faust-Socher, A., Kim, S., Azhu Valappil, R., Kausar, F., Rogaeva, E., William Langston, J., Tanner, C. M., Schüle, B., ... Marras, C. (2017). Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease. Movement Disorders, 32(4), 610-614. https://doi.org/10.1002/mds.26896

@article{9f657695edb64614afbf883b88110c56,

title = "Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease",

abstract = "Background: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. Objectives: This study investigated heart rate variability in LRRK2-associated PD. Methods: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration. Results: Low-frequency power and the ratio of low–high frequency power were reduced in idiopathic PD versus controls (P <.008, P <.029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD. Conclusions: Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD.",

keywords = "LRRK2, Parkinson's disease, autonomic dysfunction, heart rate variability",

author = "Visanji, {Naomi P.} and Bhudhikanok, {Grace S.} and Mestre, {Tiago A.} and Taneera Ghate and Kaviraj Udupa and Amaal AlDakheel and Connolly, {Barbara S.} and Carmen Gasca-Salas and Kern, {Drew S.} and Jennifer Jain and Slow, {Elizabeth J.} and Achinoam Faust-Socher and Sam Kim and {Azhu Valappil}, Ruksana and Farah Kausar and Ekaterina Rogaeva and {William Langston}, J. and Tanner, {Caroline M.} and Birgitt Sch{\"u}le and Lang, {Anthony E.} and Goldman, {Samuel M.} and Connie Marras",

note = "Publisher Copyright: {\textcopyright} 2017 International Parkinson and Movement Disorder Society",

year = "2017",

month = apr,

doi = "10.1002/mds.26896",

language = "אנגלית",

volume = "32",

pages = "610--614",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley & Sons Inc.",

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Visanji, NP, Bhudhikanok, GS, Mestre, TA, Ghate, T, Udupa, K, AlDakheel, A, Connolly, BS, Gasca-Salas, C, Kern, DS, Jain, J, Slow, EJ, Faust-Socher, A, Kim, S, Azhu Valappil, R, Kausar, F, Rogaeva, E, William Langston, J, Tanner, CM, Schüle, B, Lang, AE, Goldman, SM & Marras, C 2017, 'Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease', Movement Disorders, vol. 32, no. 4, pp. 610-614. https://doi.org/10.1002/mds.26896

TY - JOUR

T1 - Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease

AU - Visanji, Naomi P.

AU - Bhudhikanok, Grace S.

AU - Mestre, Tiago A.

AU - Ghate, Taneera

AU - Udupa, Kaviraj

AU - AlDakheel, Amaal

AU - Connolly, Barbara S.

AU - Gasca-Salas, Carmen

AU - Kern, Drew S.

AU - Jain, Jennifer

AU - Slow, Elizabeth J.

AU - Faust-Socher, Achinoam

AU - Kim, Sam

AU - Azhu Valappil, Ruksana

AU - Kausar, Farah

AU - Rogaeva, Ekaterina

AU - William Langston, J.

AU - Tanner, Caroline M.

AU - Schüle, Birgitt

AU - Lang, Anthony E.

AU - Goldman, Samuel M.

AU - Marras, Connie

PY - 2017/4

Y1 - 2017/4

N2 - Background: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. Objectives: This study investigated heart rate variability in LRRK2-associated PD. Methods: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration. Results: Low-frequency power and the ratio of low–high frequency power were reduced in idiopathic PD versus controls (P <.008, P <.029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD. Conclusions: Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD.

AB - Background: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. Objectives: This study investigated heart rate variability in LRRK2-associated PD. Methods: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration. Results: Low-frequency power and the ratio of low–high frequency power were reduced in idiopathic PD versus controls (P <.008, P <.029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD. Conclusions: Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD.

KW - LRRK2

KW - Parkinson's disease

KW - autonomic dysfunction

KW - heart rate variability

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DO - 10.1002/mds.26896

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AN - SCOPUS:85019105541

SN - 0885-3185

VL - 32

SP - 610

EP - 614

JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease

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