We developed a computerized system for the controlled acceleration of heart rate. Ten Cannulated rats were connected to a monitoring system that sampled the ECG and arterial blood pressure. Isoproterenol was delivered via a computer controlled infusion pump that we have developed. A control software, based on a modified proportional integral controller, sensed the heart rate and stabilized it on a predetermined target heart rate. Stable heart rate values within ±9.3 BPM of target heart rate were achieved in all ten rats with average settling time of 6.4±4.3 minutes. We conclude that heart rate acceleration and stabilization by the computer controlled infusion of isoproterenol is feasible and will undoubtedly have practical future clinical applications.
|Number of pages||3|
|Journal||Computers in Cardiology|
|State||Published - 1997|
|Event||Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden|
Duration: 7 Sep 1997 → 10 Sep 1997