Heart rate control by the computerized infusion of isoproterenol

R. Leor, B. Z. Bobrovsky, S. Eliash, E. Kaplinsky

Research output: Contribution to journalConference articlepeer-review


We developed a computerized system for the controlled acceleration of heart rate. Ten Cannulated rats were connected to a monitoring system that sampled the ECG and arterial blood pressure. Isoproterenol was delivered via a computer controlled infusion pump that we have developed. A control software, based on a modified proportional integral controller, sensed the heart rate and stabilized it on a predetermined target heart rate. Stable heart rate values within ±9.3 BPM of target heart rate were achieved in all ten rats with average settling time of 6.4±4.3 minutes. We conclude that heart rate acceleration and stabilization by the computer controlled infusion of isoproterenol is feasible and will undoubtedly have practical future clinical applications.

Original languageEnglish
Pages (from-to)517-519
Number of pages3
JournalComputers in Cardiology
StatePublished - 1997
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: 7 Sep 199710 Sep 1997


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