Heart rate control by the computerized infusion of isoproterenol

R. Leor; B. Z. Bobrovsky; S. Eliash; E. Kaplinsky

Heart rate control by the computerized infusion of isoproterenol

R. Leor^*, B. Z. Bobrovsky, S. Eliash, E. Kaplinsky

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

We developed a computerized system for the controlled acceleration of heart rate. Ten Cannulated rats were connected to a monitoring system that sampled the ECG and arterial blood pressure. Isoproterenol was delivered via a computer controlled infusion pump that we have developed. A control software, based on a modified proportional integral controller, sensed the heart rate and stabilized it on a predetermined target heart rate. Stable heart rate values within ±9.3 BPM of target heart rate were achieved in all ten rats with average settling time of 6.4±4.3 minutes. We conclude that heart rate acceleration and stabilization by the computer controlled infusion of isoproterenol is feasible and will undoubtedly have practical future clinical applications.

Original language	English
Pages (from-to)	517-519
Number of pages	3
Journal	Computers in Cardiology
State	Published - 1997
Event	Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden Duration: 7 Sep 1997 → 10 Sep 1997

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title = "Heart rate control by the computerized infusion of isoproterenol",

abstract = "We developed a computerized system for the controlled acceleration of heart rate. Ten Cannulated rats were connected to a monitoring system that sampled the ECG and arterial blood pressure. Isoproterenol was delivered via a computer controlled infusion pump that we have developed. A control software, based on a modified proportional integral controller, sensed the heart rate and stabilized it on a predetermined target heart rate. Stable heart rate values within ±9.3 BPM of target heart rate were achieved in all ten rats with average settling time of 6.4±4.3 minutes. We conclude that heart rate acceleration and stabilization by the computer controlled infusion of isoproterenol is feasible and will undoubtedly have practical future clinical applications.",

author = "R. Leor and Bobrovsky, {B. Z.} and S. Eliash and E. Kaplinsky",

year = "1997",

language = "אנגלית",

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journal = "Computers in Cardiology",

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AU - Leor, R.

AU - Bobrovsky, B. Z.

AU - Eliash, S.

AU - Kaplinsky, E.

PY - 1997

Y1 - 1997

N2 - We developed a computerized system for the controlled acceleration of heart rate. Ten Cannulated rats were connected to a monitoring system that sampled the ECG and arterial blood pressure. Isoproterenol was delivered via a computer controlled infusion pump that we have developed. A control software, based on a modified proportional integral controller, sensed the heart rate and stabilized it on a predetermined target heart rate. Stable heart rate values within ±9.3 BPM of target heart rate were achieved in all ten rats with average settling time of 6.4±4.3 minutes. We conclude that heart rate acceleration and stabilization by the computer controlled infusion of isoproterenol is feasible and will undoubtedly have practical future clinical applications.

AB - We developed a computerized system for the controlled acceleration of heart rate. Ten Cannulated rats were connected to a monitoring system that sampled the ECG and arterial blood pressure. Isoproterenol was delivered via a computer controlled infusion pump that we have developed. A control software, based on a modified proportional integral controller, sensed the heart rate and stabilized it on a predetermined target heart rate. Stable heart rate values within ±9.3 BPM of target heart rate were achieved in all ten rats with average settling time of 6.4±4.3 minutes. We conclude that heart rate acceleration and stabilization by the computer controlled infusion of isoproterenol is feasible and will undoubtedly have practical future clinical applications.

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SN - 0276-6574

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JO - Computers in Cardiology

JF - Computers in Cardiology

T2 - Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology

Y2 - 7 September 1997 through 10 September 1997

ER -

Heart rate control by the computerized infusion of isoproterenol

Abstract

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