Healthy aging and preclinical dementia: The United States-Israel Longitudinal Database Project

Ara S. Khachaturian; Joab Chapman; Lindsay Farrer; Robert P. Friedland; Richard Ebstein; Iris Grossman; Talma Hendler; Bruce Hermann; Rivka Inzelberg; Sterling Johnson; Zaven S. Khachaturian; Irit Lichter-Shapira; Oksana Makeeva; Robin Mayrl; Eli Mizrahi; Allen D. Roses; Mark Sager; Shifra Fraifeld

doi:10.1016/j.jalz.2010.10.001

Healthy aging and preclinical dementia: The United States-Israel Longitudinal Database Project

Ara S. Khachaturian, Joab Chapman, Lindsay Farrer, Robert P. Friedland, Richard Ebstein, Iris Grossman, Talma Hendler, Bruce Hermann, Rivka Inzelberg, Sterling Johnson, Zaven S. Khachaturian, Irit Lichter-Shapira, Oksana Makeeva, Robin Mayrl, Eli Mizrahi, Allen D. Roses, Mark Sager, Shifra Fraifeld

Research output: Contribution to journal › Comment/debate

Abstract

This article proposes the establishment of a United States-Israel Longitudinal Database for Healthy Aging and Preclinical Dementia as a prototype model for the eventual creation of an international database. It is envisioned that such a comprehensive international database, as a shared research resource, will provide the foundation for a systems approach to solve the dual public health problems of: (1) Early detection of individuals at an elevated risk of developing Alzheimer's disease, and (2) Developing interventions to delay onset of, or prevent, chronic brain disorders later in life.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	Alzheimer's and Dementia
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.jalz.2010.10.001
State	Published - Nov 2010

Keywords

Aging
Alzheimer's disease
Biomarkers
Clinical trials
Cross-cultural
Database
Dementia
Family history
Genetics
Healthy aging
Imaging
Incidence
International
Mild cognitive impairment (MCI)
Parkinson's disease;
Prevalence
Prevention
Registry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2010.10.001

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Khachaturian, A. S., Chapman, J., Farrer, L., Friedland, R. P., Ebstein, R., Grossman, I., Hendler, T., Hermann, B., Inzelberg, R., Johnson, S., Khachaturian, Z. S., Lichter-Shapira, I., Makeeva, O., Mayrl, R., Mizrahi, E., Roses, A. D., Sager, M., & Fraifeld, S. (2010). Healthy aging and preclinical dementia: The United States-Israel Longitudinal Database Project. Alzheimer's and Dementia, 6(6), 475-481. https://doi.org/10.1016/j.jalz.2010.10.001

@article{1173bbddc2564c76ae3c1af852971ecf,

title = "Healthy aging and preclinical dementia: The United States-Israel Longitudinal Database Project",

abstract = "This article proposes the establishment of a United States-Israel Longitudinal Database for Healthy Aging and Preclinical Dementia as a prototype model for the eventual creation of an international database. It is envisioned that such a comprehensive international database, as a shared research resource, will provide the foundation for a systems approach to solve the dual public health problems of: (1) Early detection of individuals at an elevated risk of developing Alzheimer's disease, and (2) Developing interventions to delay onset of, or prevent, chronic brain disorders later in life.",

keywords = "Aging, Alzheimer's disease, Biomarkers, Clinical trials, Cross-cultural, Database, Dementia, Family history, Genetics, Healthy aging, Imaging, Incidence, International, Mild cognitive impairment (MCI), Parkinson's disease;, Prevalence, Prevention, Registry",

author = "Khachaturian, {Ara S.} and Joab Chapman and Lindsay Farrer and Friedland, {Robert P.} and Richard Ebstein and Iris Grossman and Talma Hendler and Bruce Hermann and Rivka Inzelberg and Sterling Johnson and Khachaturian, {Zaven S.} and Irit Lichter-Shapira and Oksana Makeeva and Robin Mayrl and Eli Mizrahi and Roses, {Allen D.} and Mark Sager and Shifra Fraifeld",

note = "Funding Information: Research in Israel is supported by various competitive sources. The Israel Science Foundation funds approximately $60 million in new grants annually [17] . In addition, Israeli scientists have an extensive history of conducting collaborative research with U.S. colleagues. In recognition of this tradition, the prestigious U.S.–Israel Binational Science Foundation was established in 1972 to support research with the potential to achieve scientific, medical, and technological breakthroughs. The Foundation has awarded approximately $480 million to over 4000 research projects [18] . Recipients include a number of Nobel, Lasker, and Wolf Prize recipients. ",

year = "2010",

month = nov,

doi = "10.1016/j.jalz.2010.10.001",

language = "אנגלית",

volume = "6",

pages = "475--481",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

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number = "6",

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Khachaturian, AS, Chapman, J, Farrer, L, Friedland, RP, Ebstein, R, Grossman, I, Hendler, T, Hermann, B, Inzelberg, R, Johnson, S, Khachaturian, ZS, Lichter-Shapira, I, Makeeva, O, Mayrl, R, Mizrahi, E, Roses, AD, Sager, M & Fraifeld, S 2010, 'Healthy aging and preclinical dementia: The United States-Israel Longitudinal Database Project', Alzheimer's and Dementia, vol. 6, no. 6, pp. 475-481. https://doi.org/10.1016/j.jalz.2010.10.001

TY - JOUR

T1 - Healthy aging and preclinical dementia

T2 - The United States-Israel Longitudinal Database Project

AU - Khachaturian, Ara S.

AU - Chapman, Joab

AU - Farrer, Lindsay

AU - Friedland, Robert P.

AU - Ebstein, Richard

AU - Grossman, Iris

AU - Hendler, Talma

AU - Hermann, Bruce

AU - Inzelberg, Rivka

AU - Johnson, Sterling

AU - Khachaturian, Zaven S.

AU - Lichter-Shapira, Irit

AU - Makeeva, Oksana

AU - Mayrl, Robin

AU - Mizrahi, Eli

AU - Roses, Allen D.

AU - Sager, Mark

AU - Fraifeld, Shifra

N1 - Funding Information: Research in Israel is supported by various competitive sources. The Israel Science Foundation funds approximately $60 million in new grants annually [17] . In addition, Israeli scientists have an extensive history of conducting collaborative research with U.S. colleagues. In recognition of this tradition, the prestigious U.S.–Israel Binational Science Foundation was established in 1972 to support research with the potential to achieve scientific, medical, and technological breakthroughs. The Foundation has awarded approximately $480 million to over 4000 research projects [18] . Recipients include a number of Nobel, Lasker, and Wolf Prize recipients.

PY - 2010/11

Y1 - 2010/11

N2 - This article proposes the establishment of a United States-Israel Longitudinal Database for Healthy Aging and Preclinical Dementia as a prototype model for the eventual creation of an international database. It is envisioned that such a comprehensive international database, as a shared research resource, will provide the foundation for a systems approach to solve the dual public health problems of: (1) Early detection of individuals at an elevated risk of developing Alzheimer's disease, and (2) Developing interventions to delay onset of, or prevent, chronic brain disorders later in life.

AB - This article proposes the establishment of a United States-Israel Longitudinal Database for Healthy Aging and Preclinical Dementia as a prototype model for the eventual creation of an international database. It is envisioned that such a comprehensive international database, as a shared research resource, will provide the foundation for a systems approach to solve the dual public health problems of: (1) Early detection of individuals at an elevated risk of developing Alzheimer's disease, and (2) Developing interventions to delay onset of, or prevent, chronic brain disorders later in life.

KW - Aging

KW - Alzheimer's disease

KW - Biomarkers

KW - Clinical trials

KW - Cross-cultural

KW - Database

KW - Dementia

KW - Family history

KW - Genetics

KW - Healthy aging

KW - Imaging

KW - Incidence

KW - International

KW - Mild cognitive impairment (MCI)

KW - Parkinson's disease;

KW - Prevalence

KW - Prevention

KW - Registry

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U2 - 10.1016/j.jalz.2010.10.001

DO - 10.1016/j.jalz.2010.10.001

M3 - תגובה / דיון

C2 - 21044777

AN - SCOPUS:78049510297

VL - 6

SP - 475

EP - 481

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 6

ER -

Healthy aging and preclinical dementia: The United States-Israel Longitudinal Database Project

Abstract

Keywords

UN SDGs

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