hCG triggering in ART: An evolutionary concept

Anat Hershko Klement, Adrian Shulman

Research output: Contribution to journalReview articlepeer-review


Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.

Original languageEnglish
Article number1075
JournalInternational Journal of Molecular Sciences
Issue number5
StatePublished - 17 May 2017


  • Chorionic gonadotropin
  • LH receptor
  • Ovarian stimulation
  • Ovulation induction


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