TY - JOUR
T1 - Haploidentical hematopoietic stem cell transplantation with αβTCR+/CD19+ depletion in pediatric patients with malignant and non-malignant disorders
AU - Bielorai, Bella
AU - Jacoby, Elad
AU - Varda-Bloom, Nira
AU - Hutt, Daphna
AU - Churi, Chaim
AU - Vernitsky, Helly
AU - Toren, Amos
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Haploidntical hematopoietic stem cell transplantation has been increasingly used in recent years for patients without a matched donor. The αβTCR+/CD19+ depletion technique provide a graft that is enriched with CD34 cells, γδ-T-cells and natural killer. The current experience with αβTCR+/CD19+ depleted grafts in pediatric patients with malignant and non-malignant disorders, demonstrated rapid engraftment, improved immune reconstitution and low risk of GVHD. Future studies will need to define the optimal conditioning regimen in order to improve transplant outcome.
AB - Haploidntical hematopoietic stem cell transplantation has been increasingly used in recent years for patients without a matched donor. The αβTCR+/CD19+ depletion technique provide a graft that is enriched with CD34 cells, γδ-T-cells and natural killer. The current experience with αβTCR+/CD19+ depleted grafts in pediatric patients with malignant and non-malignant disorders, demonstrated rapid engraftment, improved immune reconstitution and low risk of GVHD. Future studies will need to define the optimal conditioning regimen in order to improve transplant outcome.
UR - http://www.scopus.com/inward/record.url?scp=85070793869&partnerID=8YFLogxK
U2 - 10.1038/s41409-019-0607-0
DO - 10.1038/s41409-019-0607-0
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C2 - 31431715
AN - SCOPUS:85070793869
SN - 0268-3369
VL - 54
SP - 694
EP - 697
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
ER -