Hand size and growth in untreated and IGF-I treated patients with Laron syndrome

O. Konen, A. Silbergeld, P. Lilos, L. Kornreich, Zvi Laron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We have previously reported on the linear growth, growth of the head circumference and foot length in untreated and IGF-I treated patients with Laron syndrome (LS) (primary GH insensitivity). Aim: To assess the size and growth of the hands in patients with LS from early childhood to adult age. Patients: Ten IGF-I treated children with LS (4 M, 6 F) and 24 untreated patients (10 M, 14 F) were studied. Methods: Measurements of palm length were made on available standardized hand X-rays from infancy to adult age. The measurements were compared to normal references and SD values were calculated for each measurement. The growth of the hand was compared to the concomitant height of the body. Results: Hand SDS in untreated patients with LS decreased with age, from a mean of -2.8 ± 0.7 (age 1-3 years) to -7.3 ± 0.8 (age 13-15 years) and to -9.0 ± 3.9 (age 40-50 years). During 9 years of IGF-I treatment the hand size deficit SDS did not improve in contradistinction to the height SDS which decreased from -6.2 ± 1.2 to -3.9 ± 0.5. Conclusion: Congenital IGF-I deficiency, as in Laron syndrome, profoundly affects the size and growth of the hand as part of its growth retardation characteristics, resulting in acromicria.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number3
StatePublished - Mar 2009


  • Acromicria
  • Growth
  • Hand growth
  • Hand size
  • IGF-I
  • IGF-I deficiency
  • IGF-I treatment
  • Laron syndrome
  • Primary GH insensitivity


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