Halitulin, a new cytotoxic alkaloid from the marine sponge Haliclona tulearensis

Yoel Kashman*, Ganit Koren-Goldshlager, M. D.Garcia Gravalos, Michael Schleyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Halitulin (2), a novel bisquinolinylpyrrole has been isolated from the sponge Haliclona tulearensis. Its structure was elucidated mainly on the basis of spectroscopic data as well as chemical modifications. Halitulin was found to be cytotoxic against several tumor cells: P-388, A-549, HT-29 and MEL-28 in concentrations of 12-25 ng/ml.

Original languageEnglish
Pages (from-to)997-1000
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number5
DOIs
StatePublished - 29 Jan 1999

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