Gushing's syndrome presenting as a schizophrenia-like psychotic state

Neuropsychiatrie abnormalities, of which depression is the most common, are frequently associated with Gushing's syndrome. The following paper describes a 58-year-old woman in whom a prolonged psychotic state -schizophrenia-like -was the presenting sign of Gushing's syndrome. The psychiatric symptoms disappeared shortly after the cortisol level has been normalized. Due to the variety of symptoms, both organic and psychiatric, which may occur with Gushing's syndrome, a high suspicion index is advisable. Suspect clinical findings should always prompt the appropriate endocrine work-up.