Abstract
Cells of Escherichia coli which enter a phase of starvation for P(i) induce the synthesis of the nucleotide guanosine 3',5'-bispyrophosphate (ppGpp). This induction is relA independent but depends on the spot gene product. A mutant unable to produce ppGpp is impaired in the expression of two genes which belong to the pho regulon, a defect which is dependent on the product of spoT. We suggest that ppGpp is essential for the proper induction of the genes which belong to the pho regulon.
| Original language | English |
|---|---|
| Pages (from-to) | 4053-4058 |
| Number of pages | 6 |
| Journal | Journal of Bacteriology |
| Volume | 177 |
| Issue number | 14 |
| DOIs | |
| State | Published - 1995 |
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