Guanosine 3',5'-bispyrophosphate (ppGpp) synthesis in cells of Escherichia coli starved for P(i)

B. Spira, N. Silberstein, E. Yagil*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Cells of Escherichia coli which enter a phase of starvation for P(i) induce the synthesis of the nucleotide guanosine 3',5'-bispyrophosphate (ppGpp). This induction is relA independent but depends on the spot gene product. A mutant unable to produce ppGpp is impaired in the expression of two genes which belong to the pho regulon, a defect which is dependent on the product of spoT. We suggest that ppGpp is essential for the proper induction of the genes which belong to the pho regulon.

Original languageEnglish
Pages (from-to)4053-4058
Number of pages6
JournalJournal of Bacteriology
Volume177
Issue number14
DOIs
StatePublished - 1995

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