TY - JOUR
T1 - GTP-binding proteins as possible targets for protein kinase C action
AU - Sagi-Eisenberg, Ronit
PY - 1989/9
Y1 - 1989/9
N2 - The α-subunits of two guanine nucleotide binding proteins Gi and transducin, as well as the β-subunit of transducin, serve as substrates for phosphorylation by the Ca2+- and phospholipid-dependent protein kinase C (PKC). Phosphorylation of the α-subunit of transducin is strictly dependent on its conformation and it is only the inactive form that is subjected to phosphorylation by PKC. This review will focus on the proposition that G proteins may serve as cellular targets for modulatory actions of PKC.
AB - The α-subunits of two guanine nucleotide binding proteins Gi and transducin, as well as the β-subunit of transducin, serve as substrates for phosphorylation by the Ca2+- and phospholipid-dependent protein kinase C (PKC). Phosphorylation of the α-subunit of transducin is strictly dependent on its conformation and it is only the inactive form that is subjected to phosphorylation by PKC. This review will focus on the proposition that G proteins may serve as cellular targets for modulatory actions of PKC.
UR - http://www.scopus.com/inward/record.url?scp=0024384539&partnerID=8YFLogxK
U2 - 10.1016/0968-0004(89)90001-7
DO - 10.1016/0968-0004(89)90001-7
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AN - SCOPUS:0024384539
SN - 0968-0004
VL - 14
SP - 355
EP - 357
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 9
ER -