Growth retardation and reduced growth hormone secretion in cystic fibrosis. Clinical observations from three CF centers

D'Orazio Ciro, Rita Padoan, Hannah Blau, Anna Marostica, Maurizio Fuoti, Sonia Volpi, Alba Pilotta, Joseph Meyerovitch, Daniel Sher, Baroukh M. Assael

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Growth delay in cystic fibrosis is frequent and is usually the result of several interacting causes. It most often derives from severe respiratory impairment and severe malabsorption. There are however patients whose clinical condition is not severe enough to be held accountable for this phenomenon. We aimed at describing patients who showed growth delay, who were not affected by severe pulmonary disease or malabsorption and who, when tested, showed a reduced GH secretion after stimulation with conventional agents. We noticed a disproportionately large prevalence of growth hormone (GH) release deficit (GHRD) in pediatric cystic fibrosis (CF) patients. Patients and methods: We examined all patients under our care in the period 2006-11, who were older than 5 and younger than 16. years old. We focussed on those who fell below the 3rd height percentile, or whose growth during the previous 18. months faltered by >2 SD, and who did not present clinical conditions that could reasonably explain their failure to thrive. These patients were subjected to standard GH provocative tests. Results: Out of 285 who matched the age criterion, 33 patients also matched the height percentile criterion. While 15/33 suffered clinical conditions that could reasonably explain their failure to thrive, 18/33 underwent GH release provocative tests and 12/18 showed a release deficit. Conclusions: We conclude that impaired GH secretion is more frequent among CF patients compared to the prevalence of GH deficiency in the general population and that GH release impairment may be an independent cause of growth delay in CF. Our findings are in agreement with recent studies that have described low GH levels in CF piglets and in neonates with CF [1].

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalJournal of Cystic Fibrosis
Volume12
Issue number2
DOIs
StatePublished - Mar 2013

Keywords

  • Cystic fibrosis
  • Growth hormone
  • Growth hormone deficiency
  • Growth retardation

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