TY - JOUR
T1 - Growth rate determines activity of porphobilinogen deaminase both in nonmalignant and malignant cell lines
AU - Schoenfeld, Nili
AU - Mamet, Rivka
AU - Leibovici, Leonard
AU - Epstein, Orit
AU - Teitz, Yael
AU - Atsmon, Abraham
PY - 1988/10
Y1 - 1988/10
N2 - PBGD activity and growth rate were determined in cultures of rat embryo fibroblasts, nontransformed and MLV MS transformed fibroblastic cell lines; NIH-3T3 cells, and in a mouse lymphosarcoma cell line [L-929]. The two parameters examined correlate positively (P < 0.001). The results of this investigation would seem to indicate clearly that porphobilinogen deaminase activity is related to growth. However, these experiments do not rule out the possibility that malignant transformation per se also causes changes in porphobilinogen deaminase activity.
AB - PBGD activity and growth rate were determined in cultures of rat embryo fibroblasts, nontransformed and MLV MS transformed fibroblastic cell lines; NIH-3T3 cells, and in a mouse lymphosarcoma cell line [L-929]. The two parameters examined correlate positively (P < 0.001). The results of this investigation would seem to indicate clearly that porphobilinogen deaminase activity is related to growth. However, these experiments do not rule out the possibility that malignant transformation per se also causes changes in porphobilinogen deaminase activity.
UR - http://www.scopus.com/inward/record.url?scp=0023806642&partnerID=8YFLogxK
U2 - 10.1016/0885-4505(88)90121-1
DO - 10.1016/0885-4505(88)90121-1
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AN - SCOPUS:0023806642
SN - 0885-4505
VL - 40
SP - 213
EP - 217
JO - Biochemical Medicine and Metabolic Biology
JF - Biochemical Medicine and Metabolic Biology
IS - 2
ER -
