Growth rate determines activity of porphobilinogen deaminase both in nonmalignant and malignant cell lines

Nili Schoenfeld, Rivka Mamet, Leonard Leibovici, Orit Epstein, Yael Teitz, Abraham Atsmon

Research output: Contribution to journalArticlepeer-review

Abstract

PBGD activity and growth rate were determined in cultures of rat embryo fibroblasts, nontransformed and MLV MS transformed fibroblastic cell lines; NIH-3T3 cells, and in a mouse lymphosarcoma cell line [L-929]. The two parameters examined correlate positively (P < 0.001). The results of this investigation would seem to indicate clearly that porphobilinogen deaminase activity is related to growth. However, these experiments do not rule out the possibility that malignant transformation per se also causes changes in porphobilinogen deaminase activity.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalBiochemical Medicine and Metabolic Biology
Volume40
Issue number2
DOIs
StatePublished - Oct 1988
Externally publishedYes

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