Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells

J. Nordenberg, L. Wasserman, H. Gutman, E. Beery, A. Novogrodsky

Research output: Contribution to journalArticlepeer-review

Abstract

l-Histidinol, a histidine analog was recently shown to be an inducer of differentiation in the promyelocytic cell line HL-60. In the present study we show that l-histidinol inhibits the growth of B16 melanoma cells in vitro. Growth inhibition is accompanied by phenotypic alterations that include a marked increase in the activities of NADPH cytochrome c reductase and γ glutamyl transpeptidase, lipid accumulation and cell enlargement. These phenotypic alterations are similar to those induced by other chemical inducers of differentiation in melanoma cells.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalCancer Letters
Volume47
Issue number3
DOIs
StatePublished - Oct 1989

Keywords

  • B16 melanoma
  • differentiation
  • growth-inhibition
  • l-histidinol
  • phenotypic alterations

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