Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells

J. Nordenberg; L. Wasserman; H. Gutman; E. Beery; A. Novogrodsky

doi:10.1016/0304-3835(89)90090-6

Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells

J. Nordenberg^*, L. Wasserman, H. Gutman, E. Beery, A. Novogrodsky

^*Corresponding author for this work

Clinical Departments

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8 Scopus citations

Abstract

l-Histidinol, a histidine analog was recently shown to be an inducer of differentiation in the promyelocytic cell line HL-60. In the present study we show that l-histidinol inhibits the growth of B16 melanoma cells in vitro. Growth inhibition is accompanied by phenotypic alterations that include a marked increase in the activities of NADPH cytochrome c reductase and γ glutamyl transpeptidase, lipid accumulation and cell enlargement. These phenotypic alterations are similar to those induced by other chemical inducers of differentiation in melanoma cells.

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Cancer Letters
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(89)90090-6
State	Published - Oct 1989

Keywords

B16 melanoma
differentiation
growth-inhibition
l-histidinol
phenotypic alterations

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10.1016/0304-3835(89)90090-6

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title = "Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells",

abstract = "l-Histidinol, a histidine analog was recently shown to be an inducer of differentiation in the promyelocytic cell line HL-60. In the present study we show that l-histidinol inhibits the growth of B16 melanoma cells in vitro. Growth inhibition is accompanied by phenotypic alterations that include a marked increase in the activities of NADPH cytochrome c reductase and γ glutamyl transpeptidase, lipid accumulation and cell enlargement. These phenotypic alterations are similar to those induced by other chemical inducers of differentiation in melanoma cells.",

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author = "J. Nordenberg and L. Wasserman and H. Gutman and E. Beery and A. Novogrodsky",

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AU - Nordenberg, J.

AU - Wasserman, L.

AU - Gutman, H.

AU - Beery, E.

AU - Novogrodsky, A.

PY - 1989/10

Y1 - 1989/10

N2 - l-Histidinol, a histidine analog was recently shown to be an inducer of differentiation in the promyelocytic cell line HL-60. In the present study we show that l-histidinol inhibits the growth of B16 melanoma cells in vitro. Growth inhibition is accompanied by phenotypic alterations that include a marked increase in the activities of NADPH cytochrome c reductase and γ glutamyl transpeptidase, lipid accumulation and cell enlargement. These phenotypic alterations are similar to those induced by other chemical inducers of differentiation in melanoma cells.

AB - l-Histidinol, a histidine analog was recently shown to be an inducer of differentiation in the promyelocytic cell line HL-60. In the present study we show that l-histidinol inhibits the growth of B16 melanoma cells in vitro. Growth inhibition is accompanied by phenotypic alterations that include a marked increase in the activities of NADPH cytochrome c reductase and γ glutamyl transpeptidase, lipid accumulation and cell enlargement. These phenotypic alterations are similar to those induced by other chemical inducers of differentiation in melanoma cells.

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KW - differentiation

KW - growth-inhibition

KW - l-histidinol

KW - phenotypic alterations

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Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells

Abstract

Keywords

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