TY - JOUR
T1 - Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes
AU - Lotan, Roni
AU - Ravona-Springer, Ramit
AU - Mandel, Jacob
AU - Lin, Hung Mo
AU - Ouyang, Yuxia
AU - Shahar, Danit R.
AU - Bezalel, Sharon
AU - Agarwal, Puja
AU - Dhana, Klodian
AU - Heymann, Anthony
AU - Sano, Mary
AU - Schnaider Beeri, Michal
N1 - Publisher Copyright:
© 2022
PY - 2022/8
Y1 - 2022/8
N2 - Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.
AB - Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.
KW - Cognitive decline
KW - Dietary patterns
KW - Older adults
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85134617891&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2022.109989
DO - 10.1016/j.diabres.2022.109989
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C2 - 35820563
AN - SCOPUS:85134617891
SN - 0168-8227
VL - 190
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 109989
ER -
