TY - JOUR
T1 - Granulosa cell tumor of the ovary
T2 - A study of 18 cases
AU - Piura, Benjamin
AU - Nemet, Dan
AU - Yanai‐Inbar, Ilana
AU - Cohen, Yoram
AU - Glezerman, Marek
PY - 1994/2
Y1 - 1994/2
N2 - In a study of 18 patients diagnosed with ovarian granulosa cell tumor between 1961 and 1992, clinical and pathologic findings were evaluated. Of the 18 patients, 15 (83.3%) were diagnosed in Stage I and three (16.7%) in Stage III or IV. Six patients (33.3%) underwent conservative surgery and in 12 (66.7%) total abdominal hysterectomy and bilateral salpingo‐oophorectomy was performed. At follow‐up three patients (16.6%) had died of disease, three, 16 and 288 months, respectively, after initial surgery. The actuarial 5‐year survival rate for Stage I was 100%, while that for Stages III and IV combined was 33.3% (P < 0.05). It is concluded that for patients with Stage IA, unilateral oophorectomy seems to be adequate treatment and for those with more than Stage IA, surgery should include total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Postoperative adjuvant chemotherapy is advocated for patients in whom spread of tumor beyond the ovaries has occurred. © Wiley‐Liss, Inc.
AB - In a study of 18 patients diagnosed with ovarian granulosa cell tumor between 1961 and 1992, clinical and pathologic findings were evaluated. Of the 18 patients, 15 (83.3%) were diagnosed in Stage I and three (16.7%) in Stage III or IV. Six patients (33.3%) underwent conservative surgery and in 12 (66.7%) total abdominal hysterectomy and bilateral salpingo‐oophorectomy was performed. At follow‐up three patients (16.6%) had died of disease, three, 16 and 288 months, respectively, after initial surgery. The actuarial 5‐year survival rate for Stage I was 100%, while that for Stages III and IV combined was 33.3% (P < 0.05). It is concluded that for patients with Stage IA, unilateral oophorectomy seems to be adequate treatment and for those with more than Stage IA, surgery should include total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Postoperative adjuvant chemotherapy is advocated for patients in whom spread of tumor beyond the ovaries has occurred. © Wiley‐Liss, Inc.
KW - conservative surgery
KW - estrogen
KW - low‐grade malignancies
KW - sex cord‐stromal tumors
KW - surgical staging
UR - http://www.scopus.com/inward/record.url?scp=0028349346&partnerID=8YFLogxK
U2 - 10.1002/jso.2930550203
DO - 10.1002/jso.2930550203
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AN - SCOPUS:0028349346
SN - 0022-4790
VL - 55
SP - 71
EP - 77
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 2
ER -
