Granulocytopenia associated with neuroleptic therapy in a patient with benign familial leukopenia

Ilya Reznik, Ron Loewenthal, Moshe Kotler, Inna Apter, Roberto Mester, Abraham Weizman

Research output: Contribution to journalArticlepeer-review

Abstract

Benign familial leukopenia (BFL) has been reported in several ethnic groups, including Ethiopians of Jewish origin. To date, there are no reported cases of patients with BFL developing granulocytopenia following administration of neuroleptics. We report a case of a young Ethiopian Jew suffering from schizophrenia, who exhibited premorbid benign reduced white blood cells (WBC) count and developed leukopenia and neutropenia following exposure to typical (zuclopentixol, perphenazine, haloperidol) antipsychotics and the atypical antipsychotic risperidone. The diagnosis of BFL was established and tissue typing of the patient was determined. To the best of our knowledge, this is the first report of leukopenia with neutropenia in an ethnically susceptible (due to BFL) schizophrenia patient following exposure to typical and atypical antipsychotics. HLA typing of this patient was distinct from that reported in patients susceptible to clozapine-induced agranulocytosis. Further extensive investigations including HLA typing in a larger cohort of schizophrenic patients is needed in order to define the association between HLA haplotypes and neuroleptic-induced hematological reactions and to identify the potentially vulnerable individuals.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalInternational Journal of Psychiatry in Clinical Practice
Volume7
Issue number4
DOIs
StatePublished - Dec 2003

Keywords

  • Benign familial leukopenia
  • HLA
  • Neuroleptic-related leukopenia

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