@article{8b951b301a32495e9a56d35dd60f353a,
title = "GRANULOCYTE COLONY-STIMULATING FACTOR AND NEUTROPHIL RECOVERY AFTER HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS BONE MARROW TRANSPLANTATION",
abstract = "Granulocyte colony-stimulating factor (G-CSF) was administered by continuous subcutaneous infusion to 15 patients with non-myeloid malignancies treated by high-dose chemotherapy and autologous bone marrow infusion. G-CSF was given at variable dosage based on neutrophil count. Sustained serum levels of G-CSF were achieved. Neutrophil recovery was accelerated in G-CSF treated patients compared with 18 historical controls and exceeded 0·5 × 109/l at a mean of 11 days after marrow infusion compared with 20 days for controls, a significant difference. This reduction led to significantly fewer days of parenteral antibiotic therapy, 11 versus 18 days in controls, and less isolation in reverse-barrier nursing, 10 versus 18 days.",
author = "Sheridan, {W. P.} and M. Wolf and J. Lusk and Layton, {J. E.} and L. Souza and G. Morstyn and A. Dodds and D. Maher and Green, {M. D.} and Fox, {R. M.}",
note = "Funding Information: We also thank Amgen for financial support. Funding Information: This study was supported by grants from the National Cancer Institute Funding Information: (NOl-CV-55313 [DHEW]), NIMH grant MH 16744, the American Cancer Research Fund, and the Alan and Laraine Fischer Foundation. We thank the other therapists, Dr Irvin D. Yalom, Dr Regina Kriss, and Susan Weissberg, Laiani Kuspa for data analysis, Arnold M. Rey for research assistance, and Helen Abrahamson for manuscript preparation. We also thank the following doctors for critiques of earlier drafts: Helen Blau, Kenneth Bowers, Barrie Cassileth, Hans Eysenck, Bernard Fox, James S. Goodwin, Jimmie Holland, Larry Kessler, Sandra M. Levy, Margaret Mattson, Rudolph Moos, Gary R. Morrow, Helen Pettinati, Frank Stockdale, Auke Tellegen, Lydia Temoshok, and Irvin D. Yalom.",
year = "1989",
month = oct,
day = "14",
doi = "10.1016/S0140-6736(89)91552-3",
language = "אנגלית",
volume = "334",
pages = "891--895",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Ltd.",
number = "8668",
}