Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.
- Antibiotic tissue concentration
- Invasive otitis externa
- Pseudomonas aeruginosa