Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis

M. Z. Himmelfarb, D. Zikk, Y. Rapoport, C. Redianu, I. Shalit

Research output: Contribution to journalArticlepeer-review

Abstract

Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.

Original languageEnglish
Pages (from-to)S15-S17
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume250
Issue number1 Supplement
DOIs
StatePublished - Mar 1993

Keywords

  • Antibiotic tissue concentration
  • Fluoroquinolones
  • Invasive otitis externa
  • Ofloxacin
  • Pseudomonas aeruginosa

Fingerprint

Dive into the research topics of 'Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis'. Together they form a unique fingerprint.

Cite this