Granular cell lesions in head and neck: A clinicopathological study

Dan M. Fliss*, Marco Puterman, Howard Zirkin, Alberto Leiberman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Twenty‐five cases of granular cell lesions in the region of the head and neck are presented. The adult form (18 cases) was more frequent in women, and the most frequent sites were the tongue, the skin, and subcutaneous tissues, followed by the lip and buccal mucosa. One lesion occurred in the larynx. The congenital forms (7 cases) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible. Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides. Embryonic antigen was present in the cells of all the congenital cases and in three‐quarters of the adult cases. The significance of the histological and immunohistochemical findings is discussed. We conclude that the congenital and adult lesions are similar morphologically but are not necessarily of similar histogenesis. The findings with respect to S100 protein favor a neural (Schwann cell) origin of the adult granular cell tumor, but not the congenital form.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalJournal of Surgical Oncology
Issue number3
StatePublished - Nov 1989
Externally publishedYes


  • avitin‐biotin peroxidase method
  • congenital granular cell epulis of the newborn
  • granular cell tumor
  • histiogenesis


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