TY - JOUR
T1 - Granular cell lesions in head and neck
T2 - A clinicopathological study
AU - Fliss, Dan M.
AU - Puterman, Marco
AU - Zirkin, Howard
AU - Leiberman, Alberto
PY - 1989/11
Y1 - 1989/11
N2 - Twenty‐five cases of granular cell lesions in the region of the head and neck are presented. The adult form (18 cases) was more frequent in women, and the most frequent sites were the tongue, the skin, and subcutaneous tissues, followed by the lip and buccal mucosa. One lesion occurred in the larynx. The congenital forms (7 cases) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible. Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides. Embryonic antigen was present in the cells of all the congenital cases and in three‐quarters of the adult cases. The significance of the histological and immunohistochemical findings is discussed. We conclude that the congenital and adult lesions are similar morphologically but are not necessarily of similar histogenesis. The findings with respect to S100 protein favor a neural (Schwann cell) origin of the adult granular cell tumor, but not the congenital form.
AB - Twenty‐five cases of granular cell lesions in the region of the head and neck are presented. The adult form (18 cases) was more frequent in women, and the most frequent sites were the tongue, the skin, and subcutaneous tissues, followed by the lip and buccal mucosa. One lesion occurred in the larynx. The congenital forms (7 cases) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible. Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides. Embryonic antigen was present in the cells of all the congenital cases and in three‐quarters of the adult cases. The significance of the histological and immunohistochemical findings is discussed. We conclude that the congenital and adult lesions are similar morphologically but are not necessarily of similar histogenesis. The findings with respect to S100 protein favor a neural (Schwann cell) origin of the adult granular cell tumor, but not the congenital form.
KW - avitin‐biotin peroxidase method
KW - congenital granular cell epulis of the newborn
KW - granular cell tumor
KW - histiogenesis
UR - http://www.scopus.com/inward/record.url?scp=0024792813&partnerID=8YFLogxK
U2 - 10.1002/jso.2930420305
DO - 10.1002/jso.2930420305
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C2 - 2811378
AN - SCOPUS:0024792813
SN - 0022-4790
VL - 42
SP - 154
EP - 160
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 3
ER -