Graft-versus-lymphoma effect after allogeneic peripheral blood stem cell transplantation for primary central nervous system lymphoma

Gabor Varadi, Reuven Or*, Joseph Kapelushnik, Elisabeth Naparstek, Arnon Nagler, Chaim Brautbar, Avraham Amar, Mark Kirschbaum, Simcha Samuel, Shimon Slavin, Tali Siegal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Allogeneic peripheral blood stem cell transplantation (allo PBSCT) is a recognized treatment modality for hematological malignancies resistant to conventional chemoradiotherapy. The post-transplant immune-mediated graft-versus-leukemia effect has major curative potential. In this case presentation, the allogeneic approach to resistant recurrent primary central nervous system (CNS) lymphoma using peripheral blood stem cells from an HLA identical sibling after immune-suppressive non myeloablative conditioning, was examined clinically. The patient in question had relapsing refractory primary CNS lymphoma and is the first to be treated with this modality. She developed early skin and liver-localized grade II graft-versus-host disease after allo PBSCT, which then responded to short-term treatment. Chimeric studies at the time showed 100% donor cells and repeated magnetic resonance imaging of the brain revealed gradual shrinkage of the tumor. Three months after transplant the cerebral mass was no longer evident and currently, 30 months after transplantation, the patient continues to be disease free. The absence of any signs of malignancy suggests the development of a durable graft-versus-lymphoma effect in this brain tumor and indicates that this effect may be achieved even after non-myeloablative conditioning.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalLeukemia and Lymphoma
Volume34
Issue number1-2
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Allogeneic peripheral blood stem cell transplantation
  • Graft-versus-lymphoma effect
  • Primary central nervous system lymphoma

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