Gonadotropins and combined gonadotropin-releasing hormone agonist-gonadotropins protocols in a randomized prospective study

R. Ron-El*, A. Herman, A. Golan, H. Nachum, Y. Soffer, E. Caspi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

A prospective study was designed to compare cycles stimulated by human menopausal gonadotropin (hMG) (group A) with cycles pretreated with gonadotropin-releasing hormone agonist causing pituitary desensitization followed by hMG stimulation (group B). Three hundred two cycles were randomly allocated to each group. Cancellation rate was 27.2% in group A compared with only 3.3% in group B. Significantly less hMG ampules for a shorter period were needed in group A patients. Lower estradiol and higher luteinizing hormone levels were detected in the hMG group. Patients in group B yielded significantly more oocytes and more embryos per retrieval. A significantly higher pregnancy rate per cycle was obtained in group B (27%) as compared with that of group A (13%). Moderate and severe ovarian hyperstimulation syndrome was significantly more frequent in group B than in group A.

Original languageEnglish
Pages (from-to)574-578
Number of pages5
JournalFertility and Sterility
Volume55
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Dive into the research topics of 'Gonadotropins and combined gonadotropin-releasing hormone agonist-gonadotropins protocols in a randomized prospective study'. Together they form a unique fingerprint.

Cite this