Gonadotropin-releasing hormone stimulates phosphatidylinositol labeling and prostaglandin e production in leydig cells

Jacob Molcho, Haim Zakut, Zvi Naor

Research output: Contribution to journalArticlepeer-review

Abstract

The direct effects of gonadotropin releasing hormone (GnRH) upon testicular function include a rapid (-20 min) receptor-mediated increase in phosphatidylinositol (PI) turnover. Incubation of rat interstitial cells with the super-agonist [D-Ala6]desGly10-GnRH N ethylamide (GnRHa) resulted in increased incorporation of [32P]Pi into PI (2-fold at 20 min). The effect on phospholipid turnover was followed by increased prostaglandin E (PGE) and testosterone production (3 h; with ED50 values of 0.5 and 0.75 nM respectively). It is concluded that increased PI turnover and PGE production might be involved in mediating the direct testicular effects of GnRH and its agonists.

Original languageEnglish
Pages (from-to)1048-1050
Number of pages3
JournalEndocrinology
Volume114
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

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