TY - JOUR
T1 - Gonadotropin releasing hormone
T2 - Regulation of phospholipid turnover and prostaglandin production in ovarian granulosa cells
AU - Naor, Zvi
AU - Zilberstein, Moshe
AU - Zakut, Haim
AU - Dekel, Nava
PY - 1984/7/23
Y1 - 1984/7/23
N2 - The direct effect of gonadotropin releasing hormone (GnRH) upon ovarian function, is initiated by a rapid receptor-mediated increase in phosphatidylinositol (PI) turnover (∼ 5 min) followed by prostaglandin E (PGE, 120 min) and progesterone (120 min) formation, oocyte maturation and induction of ovulation. In contrast, luteinizing hormone (LH) stimulation of oocyte maturation and induction of ovulation is mediated by increased adenosine 3′,5′-monophosphate (cAMP, 15 min), progesterone (30 min) and PGE (180 min) production. Both LH and GnRH stimulation of oocyte maturation are inhibited by dibutyryl cAMP and 3-isobutyl-1-methylxanthine, whereas induction of ovulation by the two hormones is blocked by indomethacin. GnRH and LH differ, therefore, in the mechanism leading to PGE formation, but thereafter share a common mechanism responsible for oocyte maturation and independently for induction of ovulation.
AB - The direct effect of gonadotropin releasing hormone (GnRH) upon ovarian function, is initiated by a rapid receptor-mediated increase in phosphatidylinositol (PI) turnover (∼ 5 min) followed by prostaglandin E (PGE, 120 min) and progesterone (120 min) formation, oocyte maturation and induction of ovulation. In contrast, luteinizing hormone (LH) stimulation of oocyte maturation and induction of ovulation is mediated by increased adenosine 3′,5′-monophosphate (cAMP, 15 min), progesterone (30 min) and PGE (180 min) production. Both LH and GnRH stimulation of oocyte maturation are inhibited by dibutyryl cAMP and 3-isobutyl-1-methylxanthine, whereas induction of ovulation by the two hormones is blocked by indomethacin. GnRH and LH differ, therefore, in the mechanism leading to PGE formation, but thereafter share a common mechanism responsible for oocyte maturation and independently for induction of ovulation.
UR - http://www.scopus.com/inward/record.url?scp=0021257630&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(84)90649-0
DO - 10.1016/0024-3205(84)90649-0
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AN - SCOPUS:0021257630
SN - 0024-3205
VL - 35
SP - 389
EP - 398
JO - Life Sciences
JF - Life Sciences
IS - 4
ER -