TY - JOUR
T1 - Gonadotropin releasing hormone agonist triggering for in vitro maturation cycles
AU - Hershko Klement, Anat
AU - Navve, Daniella
AU - Ghetler, Yehudith
AU - Wiser, Amir
AU - Shavit, Tal
AU - Weitzner, Omer
AU - Shulman, Adrian
N1 - Publisher Copyright:
© 2020 The British Fertility Society.
PY - 2020/12/16
Y1 - 2020/12/16
N2 - The objective was to evaluate the outcomes of in vitro maturation (IVM) cycles using gonadotropin releasing hormone agonist (GnRH-ag) triggering. A retrospective cohort of IVM cycles from January 2015 to December 2019 in a single university-affiliated centre was examined. Main outcome measures were: (i) IVM maturation rate; and (ii) IVM maturation result. Secondary outcome measures were: (i) metaphase II (MII) rate on the day of egg retrieval; (ii) final MII maturation rate; and (iii) pregnancy rates. A total of 98 IVM cycles were performed during the study period: 50 (51%) were triggered with GnRH-ag (17 received FSH priming and 33 did not) and 48 cycles (49%) were triggered by hCG (37 with FSH priming and 11 without). A significant (p = 0.01) difference was noticed in maturation rate on egg retrieval day, in favour of the GnRH-ag group, although not in the final maturation rate achieved. Pregnancy rates were comparable between treatment sub-groups. GnRH-ag triggering in IVM cycles is an optional triggering mode and can be considered an acceptable option, especially when fertility preservation is a concern. GnRH agonists resulted in higher maturation rate on day of oocyte retrieval, but no difference in the total maturation rate.
AB - The objective was to evaluate the outcomes of in vitro maturation (IVM) cycles using gonadotropin releasing hormone agonist (GnRH-ag) triggering. A retrospective cohort of IVM cycles from January 2015 to December 2019 in a single university-affiliated centre was examined. Main outcome measures were: (i) IVM maturation rate; and (ii) IVM maturation result. Secondary outcome measures were: (i) metaphase II (MII) rate on the day of egg retrieval; (ii) final MII maturation rate; and (iii) pregnancy rates. A total of 98 IVM cycles were performed during the study period: 50 (51%) were triggered with GnRH-ag (17 received FSH priming and 33 did not) and 48 cycles (49%) were triggered by hCG (37 with FSH priming and 11 without). A significant (p = 0.01) difference was noticed in maturation rate on egg retrieval day, in favour of the GnRH-ag group, although not in the final maturation rate achieved. Pregnancy rates were comparable between treatment sub-groups. GnRH-ag triggering in IVM cycles is an optional triggering mode and can be considered an acceptable option, especially when fertility preservation is a concern. GnRH agonists resulted in higher maturation rate on day of oocyte retrieval, but no difference in the total maturation rate.
KW - In vitro oocyte maturation techniques
KW - gonadotropin-releasing hormone
KW - in vitro fertilisation
KW - ovulation
UR - http://www.scopus.com/inward/record.url?scp=85097616173&partnerID=8YFLogxK
U2 - 10.1080/14647273.2020.1858511
DO - 10.1080/14647273.2020.1858511
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AN - SCOPUS:85097616173
SN - 1464-7273
VL - 25
SP - 516
EP - 521
JO - Human Fertility
JF - Human Fertility
IS - 3
ER -