Gonadotropin-releasing hormone agonist decreases chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin lymphoma

Zeev Blumenfeld*, Irith Avivi, Ari Eckman, Ron Epelbaum, Jacob M. Rowe, Eldad J. Dann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To minimize the gonadotoxic effect of chemotherapy by the cotreatment with a GnRH agonistic analogue (GnRH-a). Design: Prospective nonrandomized study with concurrent and historical controls. Setting: University medical center. Patient(s): One hundred fifteen female patients with Hodgkin lymphoma (HL). Intervention(s): Sixty-five patients received a monthly injection of GnRH-a, administered before starting chemotherapy until its conclusion, up to a maximum of 6 months. Thirty-five patients were treated with ABVD and 76 with a procarbazine-containing regimen. This group was compared with a control group of 46 women who were treated concurrently with similar chemotherapy (n = 26) without GnRH-a or were historical controls (n = 20). Main Outcome Measure(s): Cyclic ovarian function (COF) versus premature ovarian failure (POF). Result(s): The ovarian function could be determined in 111 patients. In the GnRH-a/chemotherapy group, 63 out of 65 patients resumed ovulation and regular menses (96.9 %), compared with 63% of the 46 control subjects. Twenty of the 22 patients in the BEACOPP/escalated BEACOPP/GnRH-a cotreatment resumed cyclic ovarian function versus 9 of the 14 in the chemotherapy-only group. All 17 MOPP/ABV/GnRH-a cotreated patients resumed COF versus 11 of the 22 in the chemotherapy-only group. There was no significant effect of the GnRH-a cotreatment regarding COF in the ABVD group. There were no significant differences in the cumulative doses of the various alkylating agents between the two groups. Conclusion(s): Cotreatment with GnRH-a may reduce ovarian damage significantly in female patients treated for HL and should be considered in addition to assisted reproduction for women in reproductive age receiving gonadotoxic chemotherapy.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalFertility and Sterility
Volume89
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Funding

FundersFunder number
Technion–Israel Institute of Technology, Ministry of Health

    Keywords

    • Fertility preservation
    • GnRH agonist
    • chemotherapy
    • gonadotoxicity
    • premature ovarian failure

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