Abstract
Bimetallic nanostructures can be attractive contrast-enhancing materials for dual modal imaging, allowing improved diagnosis ability using two different physical phenomena, following administration of a single nanoagent. In this research, the potential of the biocompatible polydopamine (PDA) was explored as a binding matrix to produce CuO NPs embedded in a PDA matrix (CuO@PDA nanocomposite). PDA was then tested as a reducing agent for both CuO NPs and HAuCl4 to yield a PDA composite embedded with gold nanoparticles and copper species, readily available for CT-MRI contrast enhancement. Moreover, in vitro cytotoxicity evaluation implied the low cytotoxicity of Au/Cu@PDA nanocomposite. The procedure, characterization, and imaging experiments focused on a representative Au:Cu atomic ratio of 86:14. The resulting longitudinal magnetic relaxation (T1) and X-ray attenuation properties of the nanocomposite are characterized by using phantom experiments and an ex vivo poultry heart model, demonstrating a consistent contrast improvement with both MRI and CT.
Original language | English |
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Pages (from-to) | 6124-6134 |
Number of pages | 11 |
Journal | ACS Applied Nano Materials |
Volume | 2 |
Issue number | 10 |
DOIs | |
State | Published - 25 Oct 2019 |
Externally published | Yes |
Keywords
- Au/Cu
- CT
- MRI
- contrast agent
- nanocomposite
- nanoparticle
- polydopamine