Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR

Maayan Malki, Sharon Fleischer, Assaf Shapira, Tal Dvir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs. Here, nanocomposite scaffolds comprised of albumin electrospun fibers and gold nanorods (AuNRs) were developed. Cardiac cells were seeded within the scaffolds and assembled into a functioning patch. The engineered tissue was then positioned on the myocardium and irradiated with a near IR laser (808 nm). The AuNRs were able to absorb the light and convert it to thermal energy, which locally changed the molecular structure of the fibrous scaffold, and strongly, but safely, attached it to the wall of the heart. Such hybrid biomaterials can be used in the future to integrate any engineered tissue with any defected organs, while minimizing the risk of additional injury for the patient, caused by the conventional stitching methods.

Original languageEnglish
Pages (from-to)4069-4073
Number of pages5
JournalNano Letters
Volume18
Issue number7
DOIs
StatePublished - 11 Jul 2018

Funding

FundersFunder number
Slezak Foundation
Horizon 2020 Framework Programme637943
European Research Council
Israel Academy of Sciences and Humanities
Israel Science Foundation700/13
Tel Aviv University

    Keywords

    • Cardiac tissue engineering
    • engraftment
    • gold nanorods
    • near IR
    • tissue integration

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