Gold Nanoparticle-Integrated Scaffolds for Tissue Engineering and Regenerative Medicine

Moran Yadid, Ron Feiner, Tal Dvir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

The development of scaffolding materials that recapitulate the cellular microenvironment and provide cells with physicochemical cues is crucial for successfully engineering functional tissues that can aid in repairing damaged organs. The use of gold nanoparticles for tissue engineering and regenerative medicine has raised great interest in recent years. In this mini review, we describe the shape-dependent properties of gold nanoparticles, and their versatile use in creating tunable nanocomposite scaffolds with improved mechanical and electrical properties for tissue engineering. We further describe using gold nanoparticle-integrated scaffolds to achieve improved stem cells proliferation and differentiation. Finally, we discuss the main challenges and prospects for clinical translation of gold nanoparticles-hybrid scaffolds.

Original languageEnglish
Pages (from-to)2198-2206
Number of pages9
JournalNano Letters
Volume19
Issue number4
DOIs
StatePublished - 10 Apr 2019

Funding

FundersFunder number
Israeli Science Foundation700/13
Moxie Foundation
Slezak Foundation
Horizon 2020 Framework Programme
European Research Council637943
Ministry of Science, Technology and Space3-12587

    Keywords

    • Gold nanoparticles
    • regenerative medicine
    • scaffolds
    • tissue engineering

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