GnRH-antagonist programming versus GnRH agonist protocol: A randomized trial

Anat Hershko Klement*, Arie Berkovitz, Amir Wiser, Ofer Gonen, Keren Amichay, Ilan Cohen, Yehudith Ghetler, Adrian Shulman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective Testing the ability to program IVF GnRH-antagonist cycles to avoid weekend oocyte retrieval. Study design Preliminary randomized clinical trial. Patients presenting an indication for IVF or IVF-ICSI were assigned into either the Treatment Group - GnRH antagonist protocol, programmed to start stimulatory agents on a Friday, with oral 2 mg estradiol valerate twice a day from the 2nd day of cycle until the first Friday to follow, or to the Control Group - long luteal GnRH agonist protocol. Results The performance of 27 Treatment Group patients and 24 Control Group patients was analyzed. Cycle dynamics were not clinically or statistically different except for a significant difference in the number of follicles measuring ≥18 mm on hCG administration day. There were no differences in the number of aspirated ova, fertilization rates, embryo quality or number of embryos to be transferred. Pregnancy rate was 41.7% in the Treatment Group and 50% in the Control Group (P > 0.5). Only one patient assigned to the Treatment Group had a weekend retrieval. Conclusions Preliminary results demonstrate no compromise related to follicular estrogen programming in a GnRH antagonist protocol and provide reassurance regarding the ability to achieve programming goals.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
StatePublished - 1 Feb 2015
Externally publishedYes


  • Drug administration schedule
  • In vitro fertilization
  • Oocyte retrieval
  • Patient schedule
  • Pituitary hormone release inhibiting hormones


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