GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol

Raoul Orvieto*, Ravit Nahum, Efraim Zohav, Gad Liberty, Eyal Y. Anteby, Simion Meltcer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective: To evaluate, whether Gonadotropin-releasing hormone-agonist (GnRH-agonist or GnRH-ag) trigger in patients undergoing the ultrashort GnRH-ag/GnRH-antagonist (GnRH-ant) protocol is as effective as in patients at high risk to develop severe ovarian hyperstimulation syndrome (OHSS), who undergo the multidose GnRH-ant protocol. Design: Cohort study. Setting: University hospital. Patients: All consecutive women aged ≤35 years admitted to our IVF unit from January 2011 to October 2011 who reached the ovum pick-up stage. Interventions: Triggering final oocytes maturation by GnRH-ag instead of hCG, in high-responder patients undergoing either the ultrashort GnRH-ag/GnRH-ant or the multidose GnRH-antagonist controlled ovarian hyperstimulation (COH) protocols. Main outcome measures: Ovarian stimulation characteristics, percentage of mature oocytes, fertilization and pregnancy rates. Results: No inbetween groups differences were observed in ovarian-stimulation related variable, percentage of mature oocytes, fertilization or pregnancy rates. No case of moderate-severe OHSS was reported in the study, or the control groups. Conclusions: Three consecutive doses of daily GnRH-ag administration at the beginning of ultrashort flare GnRH-ag/GnRH-ant COH protocol, did not interfere with the ability of the GnRH-ag to trigger final oocytes maturation at the end of the COH cycle.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalGynecological Endocrinology
Volume29
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • COH
  • GnRH-agonist
  • IVF outcome
  • Multidose GnRH-antagonist
  • Ovulation trigger
  • Ultrashort GnRH-agonist

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