TY - JOUR
T1 - Gluten-free diet can ameliorate the symptoms of non-celiac autoimmune diseases
AU - Lerner, Aaron
AU - Freire De Carvalho, Jozélio
AU - Kotrova, Anna
AU - Shoenfeld, Yehuda
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Context: A gluten-free diet (GFD) is the recommended treatment for gluten-dependent disease. In addition, gluten withdrawal is popular and occasionally is suggested as a treatment for other autoimmune diseases (ADs). Objective: The current systematic review summarizes those entities and discusses the logic behind using a GFD in classical non-gluten-dependentADs. Data Sources: A search for medical articles in PubMed/MEDLINE, Web of Sciences, LILACS, and Scielo published between 1960 and 2020 was conducted, using the key words for various ADs and GFDs. Data Exxtraction: Eight-three articles were included in the systematic review (using PRISMA guidelines). Data Analysis: Reduction in symptoms of ADs after observance of a GFD was observed in 911 out of 1408 patients (64.7%) and in 66 out of the 83 selected studies (79.5%). The age of the patients ranged from 9 months to 69 years. The duration of the GFD varied from 1 month to 9 years. A GFD can suppress several harmful intraluminal intestinal events. Potential mechanisms and pathways for the action of GFD in the gut-remote organs' axis have been suggested. Conclusion: A GFD might represent a novel nutritional therapeutic strategy for classical non-gluten-dependent autoimmune conditions.
AB - Context: A gluten-free diet (GFD) is the recommended treatment for gluten-dependent disease. In addition, gluten withdrawal is popular and occasionally is suggested as a treatment for other autoimmune diseases (ADs). Objective: The current systematic review summarizes those entities and discusses the logic behind using a GFD in classical non-gluten-dependentADs. Data Sources: A search for medical articles in PubMed/MEDLINE, Web of Sciences, LILACS, and Scielo published between 1960 and 2020 was conducted, using the key words for various ADs and GFDs. Data Exxtraction: Eight-three articles were included in the systematic review (using PRISMA guidelines). Data Analysis: Reduction in symptoms of ADs after observance of a GFD was observed in 911 out of 1408 patients (64.7%) and in 66 out of the 83 selected studies (79.5%). The age of the patients ranged from 9 months to 69 years. The duration of the GFD varied from 1 month to 9 years. A GFD can suppress several harmful intraluminal intestinal events. Potential mechanisms and pathways for the action of GFD in the gut-remote organs' axis have been suggested. Conclusion: A GFD might represent a novel nutritional therapeutic strategy for classical non-gluten-dependent autoimmune conditions.
KW - Autoimmune disease
KW - Gluten withdrawal
KW - Gluten-free Diet
KW - Gut-brain axes
KW - Gut-peripheral organs axes
KW - Microbiome/dysbiome ratio
KW - Non-celiac autoimmune disease
UR - http://www.scopus.com/inward/record.url?scp=85124439867&partnerID=8YFLogxK
U2 - 10.1093/nutrit/nuab039
DO - 10.1093/nutrit/nuab039
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C2 - 34338776
AN - SCOPUS:85124439867
SN - 0029-6643
VL - 80
SP - 525
EP - 543
JO - Nutrition Reviews
JF - Nutrition Reviews
IS - 3
ER -