The membrane diffusion coefficients of DIP homologs (diazenedicarboxylic acid bis (N′-alkylpiperazides, e.g., N′-alkyl = ethyl) (I) vary substantially in red cells of different species. The coefficients range from 2.0 to 23.0 cm2/sec × 109 at 1°C (sheep r.b.c., chimpanzee r.b.c.) and the increase is correlated with increasing fluidity of the membrane, as indicated by a "fluidity factor" based on the double bond content of the fatty acids of the membrane. High variability of the coefficient in rabbits might be related to cholesterol content.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - 4 Aug 1975|