Glutathione XI. Species variation of membrane diffusion coefficients derived from intracellular thiol oxidation with DIP homologs

Nechama S. Kosower*, Edward M. Kosower, Lilly Levi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The membrane diffusion coefficients of DIP homologs (diazenedicarboxylic acid bis (N′-alkylpiperazides, e.g., N′-alkyl = ethyl) (I) vary substantially in red cells of different species. The coefficients range from 2.0 to 23.0 cm2/sec × 109 at 1°C (sheep r.b.c., chimpanzee r.b.c.) and the increase is correlated with increasing fluidity of the membrane, as indicated by a "fluidity factor" based on the double bond content of the fatty acids of the membrane. High variability of the coefficient in rabbits might be related to cholesterol content.

Original languageEnglish
Pages (from-to)901-906
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume65
Issue number3
DOIs
StatePublished - 4 Aug 1975

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